| 词条 | Linda Hsieh-Wilson |
| 释义 |
| name = Linda Carol Hsieh-Wilson | image = | image_size = | alt = | caption = | birth_date = | birth_place = | residence = | citizenship = | nationality = | fields = Chemical neurobiology | workplaces = California Institute of Technology | alma_mater = University of California, Berkeley | doctoral_advisor = Peter G. Schultz | academic_advisors = | doctoral_students = | notable_students = | known_for = | influences = | influenced = | awards = | signature = | signature_alt = | footnotes = | spouse = }} Linda Carol Hsieh-Wilson is an American chemist. She is known for her work in chemical neurobiology and is currently a professor of chemistry at the California Institute of Technology. She is also a Howard Hughes Medical Institute investigator and an adjunct professor at the Semel Institute for Neuroscience and Human Behavior at the University of California, Los Angeles. BiographyHsieh-Wilson was born in New York City, NY and received her bachelor's degree in chemistry at Yale University, where she graduated magna cum laude. She then completed her Ph.D. in 1996 at the University of California, Berkeley, where she was a National Science Foundation Fellow in the laboratory of Peter G. Schultz and studied antibody-based catalysis.[1][2] She then joined the lab of Professor and Nobel Prize Laureate Paul Greengard at Rockefeller University until 2000. There she characterized the protein phosphatase and actin-binding protein spinophilin[3] and investigated its role in dendritic spines.[4][5] Hsieh-Wilson then obtained an appointment at the Department of Chemistry at the California Institute of Technology in 2000 as an assistant professor and became an investigator at the Howard Hughes Medical Institute in 2005. She then became an associate professor of chemistry in 2006 and was appointed a full professor of chemistry at the California Institute of Technology in 2010.[6] Research interestsOverviewHsieh-Wilson's research is at the interface between organic chemistry and neuroscience.[7] She investigates how the post-translational addition of glycans affect the structure and function of proteins in the nervous system. Her laboratory has developed a chemoenzymatic method to tag proteins that have been appended with a dynamic form of glycosylation called O-GlcNAc.[8] Her work with glycosaminoglycan microarrays has significantly advanced an understanding of specific sulfated glycosaminoglycans in neuronal communication, learning, and memory as well as advanced the field of chemical biology.[9] She has demonstrated how fucosylation can modulate neurite growth and neuronal morphology.[10] O-GlcNAc GlycosylationHsieh-Wilson and her colleagues have found that the covalent-modifications of intercellular proteins by O-linked-N-acetylglucosamine (O-GlcNAc) within the mammalian nervous system have a large role in the regulation of gene expression, neuronal signaling, and synaptic plasticity.[11] This post-translational modification, has been analysed in the rat brain using a novel chemoenzymatic strategy wherein O-GlcNAc modified proteins are selectively labeled with flourecent or biotin tags. This technique developed by Hsieh-Wilson and her lab has revealed over 200 O-GlcNAc modified proteins within the mammilian brain and such modifications have been shown to activate transcriptional function of proteins,[12] regulate cancer metabolism,[13] regulate gene expression and memory formation,[14] and carry out many other tasks in the brain and beyond. GlycosaminoglycansGlycosaminoglycans are heterogeneously sulfated oligosaccharides that are very important in nervous system development, spinal cord injury, inflammation and cancer metastasis. Hsieh-Wilson's research on this subject implicates the specific sulfation sequence of glycosaminoglycans as a way to modulate biological function. Specifically, her work with chondroitin sulfate (CS) and heparan sulfate (HS), the two most common glycosaminoglycans in the nervous system, has shown that this "sulfation code" functions as a molecular recognition element for growth factors and modulates neuronal growth,[15][16] indicating that these specific sulfated glycosaminoglycans play a major role in neuronal communication, learning, and memory. Additionally, Hsieh-Wilson has ellucidated the role of this sulfation in glycosaminoglycan-protein interaction using a carbohydrate microarray-based approach developed in her lab.[17]Notable papersThe Web of Science lists 51 publications in peer-reviewed scientific journals that have been cited over 1200 times, leading to an h-index of 21.[18] Her three most cited papers (>90 times) are:[18]
Awards and honors
References1. ^{{Cite web|url=http://network.expertisefinder.com/experts/linda-hsieh-wilson|title=Linda Carol Hsieh-Wilson, California Institute of Technology: Learning and memory, Memory and motor control, Neurobiology • Expertise Finder Network|last=Finder|first=Expertise|website=network.expertisefinder.com|access-date=2017-05-02}} 2. ^{{Cite journal|last=Hsieh-Wilson|first=L. C.|last2=Schultz|first2=P. G.|last3=Stevens|first3=R. C.|date=1996-05-28|title=Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=93|issue=11|pages=5363–5367|issn=0027-8424|pmc=39251|pmid=8643580|doi=10.1073/pnas.93.11.5363}} 3. ^{{Cite journal|last=Hsieh-Wilson|first=L. C.|last2=Allen|first2=P. B.|last3=Watanabe|first3=T.|last4=Nairn|first4=A. C.|last5=Greengard|first5=P.|date=1999-04-06|title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1|journal=Biochemistry|volume=38|issue=14|pages=4365–4373|doi=10.1021/bi982900m|issn=0006-2960|pmid=10194355}} 4. ^{{Cite journal|last=Grossman|first=Stacie D.|last2=Hsieh-Wilson|first2=Linda C.|last3=Allen|first3=Patrick B.|last4=Nairn|first4=Angus C.|last5=Greengard|first5=Paul|date=2002-01-01|title=The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines|journal=Neuromolecular Medicine|volume=2|issue=1|pages=61–69|doi=10.1385/NMM:2:1:61|issn=1535-1084|pmid=12230305}} 5. ^{{Cite journal|last=Hsieh-Wilson|first=Linda C.|last2=Benfenati|first2=Fabio|last3=Snyder|first3=Gretchen L.|last4=Allen|first4=Patrick B.|last5=Nairn|first5=Angus C.|last6=Greengard|first6=Paul|date=2003-01-10|title=Phosphorylation of spinophilin modulates its interaction with actin filaments|journal=The Journal of Biological Chemistry|volume=278|issue=2|pages=1186–1194|doi=10.1074/jbc.M205754200|issn=0021-9258|pmid=12417592}} 6. ^{{Cite web|url=http://www.cce.caltech.edu/content/linda-c-hsieh-wilson|title=Linda C. Hsieh-Wilson {{!}} www.cce.caltech.edu|website=www.cce.caltech.edu|language=en|access-date=2017-05-02}} 7. ^{{cite web |url=http://www.hhmi.org/research/investigators/hsieh-wilson.html |title=HHMI Scientist Abstract: Linda C. Hsieh-Wilson, Ph.D. |publisher=Howard Hughes Medical Institute |website= |accessdate=2011-07-16}} 8. ^{{cite journal |doi=10.1038/nchembio881 |title=Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics |year=2007 |last1=Khidekel |first1=Nelly |last2=Ficarro |first2=Scott B |last3=Clark |first3=Peter M |last4=Bryan |first4=Marian C |last5=Swaney |first5=Danielle L |last6=Rexach |first6=Jessica E |last7=Sun |first7=Yi E |last8=Coon |first8=Joshua J |last9=Peters |first9=Eric C | displayauthors = 8|journal=Nature Chemical Biology |volume=3 |issue=6 |pages=339–348 |pmid=17496889}} 9. ^{{cite journal |doi=10.1038/nchembio810 |title=Sulfation patterns of glycosaminoglycans encode molecular recognition and activity |year=2006 |last1=Gama |first1=Cristal I |last2=Tully |first2=Sarah E |last3=Sotogaku |first3=Naoki |last4=Clark |first4=Peter M |last5=Rawat |first5=Manish |last6=Vaidehi |first6=Nagarajan |last7=Goddard |first7=William A |last8=Nishi |first8=Akinori |last9=Hsieh-Wilson |first9=Linda C | displayauthors = 8|journal=Nature Chemical Biology |volume=2 |issue=9 |pages=467–473 |pmid=16878128}} 10. ^{{cite journal |doi=10.1126/stke.3172006tw472 |title=Sweet Memories of Synapsins? |year=2006 |journal=Science's STKE |volume=2006 |issue=317 |pages=tw472}} 11. ^http://www.pnas.org/content/101/36/13132.full.pdf 12. ^http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=DaisyOneClickSearch&qid=11&SID=1AMO2etzAYAIFJZoUSG&page=1&doc=6&cacheurlFromRightClick=no 13. ^{{Cite journal|last=Hsieh-Wilson|first=Linda|date=2013-04-01|title=O-GlcNAc Signaling Regulates Cancer Metabolism|url=http://www.fasebj.org/content/27/1_Supplement/452.2|journal=The FASEB Journal|language=en|volume=27|issue=1 Supplement|page=452.2|doi=10.1096/fasebj.27.1_supplement.452.2|issn=0892-6638|doi-broken-date=2019-02-18}} 14. ^http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=DaisyOneClickSearch&qid=11&SID=1AMO2etzAYAIFJZoUSG&page=1&doc=21 15. ^https://www.nature.com/nchembio/journal/v2/n9/full/nchembio810.html 16. ^{{Cite journal|last=Tully|first=Sarah E.|last2=Mabon|first2=Ross|last3=Gama|first3=Cristal I.|last4=Tsai|first4=Sherry M.|last5=Liu|first5=Xuewei|last6=Hsieh-Wilson|first6=Linda C.|date=2004-06-01|title=A Chondroitin Sulfate Small Molecule that Stimulates Neuronal Growth|journal=Journal of the American Chemical Society|volume=126|issue=25|pages=7736–7737|doi=10.1021/ja0484045|issn=0002-7863}} 17. ^{{Cite journal|last=Shipp|first=Eric L.|last2=Hsieh-Wilson|first2=Linda C.|date=2007-02-01|title=Profiling the Sulfation Specificities of Glycosaminoglycan Interactions with Growth Factors and Chemotactic Proteins Using Microarrays|journal=Chemistry & Biology|volume=14|issue=2|pages=195–208|doi=10.1016/j.chembiol.2006.12.009}} 18. ^1 {{cite web |url=http://isiwebofknowledge.com |title=Web of Science |year=2011 |accessdate=2011-07-16}} 19. ^{{cite web |title=Linda C. Hsieh-Wilson |url=http://www.beckman-foundation.org/beckman-young-investigators/linda-c-hsieh-wilson |website=Arnold and Mabel Beckman Foundation |accessdate=1 August 2018}} 20. ^{{cite web |url=http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1319&content_id=CTP_004496&use_sec=true&sec_url_var=region1 |title=Arthur C. Cope Scholar Awards |publisher=American Chemical Society |website= |accessdate=2011-07-16 |deadurl=yes |archiveurl=https://web.archive.org/web/20110811230542/http://portal.acs.org/portal/acs/corg/content?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1319&content_id=CTP_004496&use_sec=true&sec_url_var=region1 |archivedate=2011-08-11 |df= }} External links
8 : 21st-century American chemists|California Institute of Technology faculty|Living people|Howard Hughes Medical Investigators|University of California, Berkeley alumni|University of California, Los Angeles faculty|Yale University alumni|Year of birth missing (living people) |
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