| 词条 | Lipopolysaccharide kinase (Kdo/WaaP) family |
| 释义 |
| Symbol = Kdo | Name = Kdo | image = | width = | caption = | Pfam = PF06293 | Pfam_clan = CL0016 | InterPro = IPR010440 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the lipopolysaccharide kinase (Kdo/WaaP) family is a family of kinases. The family consists of lipopolysaccharide kinases including lipopolysaccharide core heptose(I) kinase rfaP (encoded by the waaP (rfaP) gene). Lipopolysaccharide core heptose(I) kinase rfaP is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that it is necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of Salmonella enterica.[1] The family also includes 3-deoxy-D-manno-octulosonic acid kinase (KDO kinase) from Haemophilus influenzae, which phosphorylates Kdo-lipid IV(A), a lipopolysaccharide precursor, and is involved in virulence.[2] References1. ^{{cite journal |vauthors=Yethon JA, Whitfield C | title = Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability | journal = J. Biol. Chem. | volume = 276 | issue = 8 | pages = 5498–504 |date=February 2001 | pmid = 11069912 | doi = 10.1074/jbc.M008255200 | url = }} 2. ^{{cite journal|vauthors=White KA, Lin S, Cotter RJ, Raetz CR | title=A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence. | journal=J Biol Chem | year= 1999 | volume= 274 | issue= 44 | pages= 31391–400 | pmid=10531340 | doi= 10.1074/jbc.274.44.31391| pmc= | url= }} Further reading
1 : Protein families |
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