词条 | List of adverse effects of chlorpromazine |
释义 |
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Notes1. ^Data on the exact incidence of the different adverse effects is greatly lacking so only rough approximations of adverse effect incidence is available 2. ^{{cite web|title=PRODUCT INFORMATION LARGACTIL|work=TGA eBusiness Services|publisher=Sanofi Aventis Pty Ltd|date=28 August 2012|accessdate=8 December 2013|url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-05882-3|format=PDF}} 3. ^{{cite web|title=Chlorpromazine Hydrochloride 100mg/5ml Oral Syrup - Summary of Product Characteristics (SPC)|work=electronic Medicines Compendium|publisher=Rosemont Pharmaceuticals Limited|date=6 August 2013|accessdate=8 December 2013|url=http://www.medicines.org.uk/emc/medicine/10751/SPC/Chlorpromazine+Hydrochloride+100mg+5ml+Oral+Syrup/}} 4. ^{{cite web|title=CHLORPROMAZINE HYDROCHLORIDE tablet, film coated [Sandoz Inc]|work=DailyMed|publisher=Sandoz Inc|date=October 2011|accessdate=8 December 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f15e9f35-1e3e-4217-b8e2-1d6096dbee1b}} 5. ^{{cite web|title=CHLORPROMAZINE HYDROCHLORIDE injection [West-ward Pharmaceutical Corp.]|work=DailyMed|publisher=West-ward Pharmaceutical Corp.|date=June 2012|accessdate=8 December 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c0f1fcfd-8863-4032-bf80-185df60a4ba0}} 6. ^{{cite web|title=Largactil Injection - Summary of Product Characteristics|work=electronic Medicines Compendium|publisher=Sanofi|date=10 May 2013|accessdate=8 December 2013|url=http://www.medicines.org.uk/emc/medicine/804/SPC/Largactil+Injection/}} 7. ^Refer to main text below for details on this adverse effect 8. ^A drop in blood pressure that results from standing up 9. ^A disturbance in the electrical cycle of the heart 10. ^Elevated serum levels of the lactation-related hormone prolactin. This in turn can result, in the short term, at least, in galactorrhoea (lactation that is unrelated to pregnancy or breastfeeding), gynaecomastia (swollen breast tissue), sexual dysfunction and amenorrhoea (the absence of the menstrual period in women). Whereas in the long-term hyperprolactinaemia can result in osteoporosis (brittle bones). 11. ^An impaired ability to regulate one's body temperature 12. ^High blood glucose (sugar) levels 13. ^The hypothalamus of the brain regulates the release of a number of hormones as well as a few "housekeeping" functions such as tight control over body temperature 14. ^Widening (dilation) of the pupils 15. ^Refer to the text below for details 16. ^Constriction of the pupils of the eyes 17. ^Being unable to pass urine 18. ^Glucose (sugar) in the urine due to there being too much glucose in the blood for the kidneys to reabsorb it all when filtrate goes through loop of henle in the nephrons of the kidney. 19. ^Low blood glucose (sugar) 20. ^Basically an exaggerated form of leucopaenia. It occurs when the white blood cell (WBC) count drops below 5% of the norm 21. ^Where the number of red blood cells of the body die breakdown to an abnormal extent. These cells carry oxygen across the body from the lungs 22. ^Where the bone marrow stops adequately (in order to replenish the blood cells that die off every day) producing new blood cells 23. ^An abnormality in the electrical activity of the heart which can lead to potentially fatal changes in heart rhythm 24. ^Dangerously (in the short-term) high blood pressure 25. ^A dangerous skin reaction 26. ^An autoimmune reaction 27. ^A potentially fatal collection of symptoms (i.e. syndrome) that results from an abnormally excessive release of antidiuretic hormone (ADH). This in turn increases the reabsorption of 28. ^A potentially fatal condition that is caused by dopamine receptor-blocking agents such as antipsychotics. It develops over a period of days or weeks and is characterised by rigidity, tremor, diarrhoea, tachycardia, altered mental status (e.g. confusion, mania, hallucinations, etc.) and hyperthermia (high body temperature) 29. ^An autoimmune condition in of which the body's defences attack the neuromuscular junction – the gap between muscle and nerve cells across which the nerves send messages to the muscle cells 30. ^An abnormally low number of white blood cells in the blood. These cells defend the body from infections and hence this can heighten one's risk of infections 31. ^An abnormally high number of eosinophils – the cells of the immune system that defends the body from parasites 32. ^An abnormally low number of all three major groups of blood cells including the red blood cells, white blood cells and platelets 33. ^A painful and sustained (usually a few hours) erection 34. ^Fear of light 35. ^A reduction in the normal homeostatic breathing reaction to reductions in plasmacarbon dioxide levels 36. ^High body temperature 37. ^Low body temperature 38. ^Lactation that is unassociated with lactation or breastfeeding 39. ^The accumulation of fluid in the tissues of the brain 40. ^Basically the opposite to euphoria 41. ^The absence of menstrual periods 42. ^An often irreversible and sometimes even fatal movement disorder characterised by involuntary, repetitive and purposeless movements of the face, extremities, lips or tongue. Usually takes a number of years to develop but in some it can appear within months or less since the initiation of antipsychotic treatment References 1 : Medication side effects |
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