“List of adverse effects of valproate semisodium”的意思、由来-开放百科全书

Common (1-10% frequency)

Liver injury

Gastralgia

Diarrhoea

Extrapyramidal (movement) disorder

Stupor{{efn|name=a}}

Somnolence

Convulsion{{efn|name=a}}

Memory impairment

Headache

Nystagmus

Confusional state

Aggression{{efn|name=b}}

Agitation{{efn|name=b}}

Impaired attention{{efn|name=b}}

Hyponatraemia

Anaemia

Thrombocytopaenia

Hypersensitivity

Transient and/or dose-related hair loss

Dysmenorrhea

Haemorrhage (bleeding)

Weight gain{{efn|name=c}}

Rare (<0.01% frequency)

Reversible dementia

Reversible cerebral atrophy

Abnormal behaviour{{efn|name=b}}

Psychomotor hyperactivity{{efn|name=b}}

Learning disorder{{efn|name=b}}

Hyperammonaemia

Hypothyroidism

Bone marrow failure

Toxic epidermal necrolysis

Stevens-Johnson syndrome

Erythema multiforme

DRESS syndrome

Male infertility

Polycystic ovaries

Enuresis

Reversible Fanconi syndrome

Coagulation abnormalities

Systemic lupus erythematosus

Gynaecomastia

References

1. ^{{cite web|title=Depakote 250mg Tablets - Summary of Product Characteristics|work=electronic Medicines Compendium|publisher=Sanofi|date=28 November 2013|accessdate=18 January 2014|url=http://www.medicines.org.uk/emc/medicine/25929/SPC/Depakote+250mg+Tablets/}}
2. ^{{cite web|title=DEPAKOTE (divalproex sodium) tablet, delayed release [AbbVie Inc.]|work=DailyMed|publisher=AbbVie Inc.|date=September 2013|accessdate=18 January 2014|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=08a65cf4-7749-4ceb-6895-8f4805e2b01f}}
3. ^{{cite web|title=Depakote (divalproex sodium) dosing, indications, interactions, adverse effects, and more|work=Medscape Reference|publisher=WebMD|accessdate=18 January 2014|url=http://reference.medscape.com/drug/depakote-divalproex-sodium-999832#showall}}
4. ^Rare cases of lethargy occasionally progressing to stupor, sometimes with associated hallucinations or convulsions have been reported. Encephalopathy and coma have very rarely been observed. These cases are most often seen in association with other factors such as rapid dose escalations or withdrawal from other medications. They have usually been reversible on withdrawal of treatment or reduction of dosage.
5. ^These cases most commonly occur in the paediatric population.
6. ^Weight gain should be monitored closely as there is a potential link between weight gain and polycystic ovary syndrome.

5 : Anticonvulsants|GABA transaminase inhibitors|Organic sodium salts|Teratogens|Mood stabilizers

Very common (>10% frequency)

Common (1-10% frequency)

Uncommon (0.01-0.1% frequency)

Rare (<0.01% frequency)

Notes

References