| Route | Road Name(s) | From | To | Notes | | CR 2}}{{Jct|state=FL|CR|2|county1=Holmes}} | CR 2 at the Walton County line southwest of Royals Crossroads | SR 81 / CR 2A in Royals Crossroads | Former SR 2;[1] inventoried by FDOT as part of SR 2, but signed as CR 2 |
| state=FL|CR|2A|county1=Holmes}} | SR 81 / CR 2 in Royals Crossroads | CR 185 east-northeast of Royals Crossroads | Former SR 2A[1] |
| state=FL|CR|10A|county1=Holmes}} | Old Spanish Trail
Railroad Street
Pirate Cove Road
Old US 90
Oak Grove Church Road | CR 10A at the Walton County line northeast of Argyle
US 90 (SR 10) in Ponce de Leon
US 90 (SR 10) northeast of Ponce de Leon | US 90 (SR 10) west of Ponce de Leon
US 90 (SR 10) in Long Pond Hill
US 90 (SR 10) northeast of Ponce de Leon | Former SR 10A[1]
Former SR 10A;[1] abandoned segment exists east of Oak Grove Church Road. |
| CR 65}}{{Jct|state=FL|CR|65|county1=Holmes}} | Roping Road
Smith Chapel Road
Love Road | CR 177A / Monroe Paul Road southwest of Bethlehem | date=February 2014}} | Dirt road |
| CR 81A}}{{Jct|state=FL|CR|81A|county1=Holmes}} | Otter Creek Road
Sandy Creek Road | CR 10A west-northwest of Ponce de Leon | Unnamed road west-southwest of Bunker Hill | Former SR 81A[1] |
| CR 160}}{{Jct|state=FL|CR|160|county1=Holmes}} | SR 81 / Jones Loop / Gillman Road in Hobbs Crossroads
CR 177 / Pinestraw Alley Road in Bethlehem | CR 179A in Barker Store
SR 79 south of Esto | Former SR 160[1] |
| CR 162}}{{Jct|state=FL|CR|162|county1=Holmes}} | CR 181 / Hickory Hill Road in Hickory Hill
CR 173 north-northeast of Bonifay | CR 179A / Buck Rogers Drive in Cerrogordo
CR 162 at the Jackson County line northeast of Bonifay | date=February 2014}}
Former SR 162[2] |
| CR 163}}{{Jct|state=FL|CR|163|county1=Holmes}} | SR 2 / Peak Road northeast of Hobbs Crossroads | CR 31 at the Alabama state line north-northeast of Hobbs Crossroads | Former SR 163[1] |
| CR 171}}{{Jct|state=FL|CR|171|county1=Holmes}} | SR 2 in Eleanor | SR 103 at the Alabama state line north-northeast of Cobb Cross Roads | Former SR 171[1] |
| CR 173}}{{Jct|state=FL|CR|173|county1=Holmes}} | Jenkins Boulevard
Holmes Avenue
McGee Road
East North Avenue | CR 173 / Pipkin Road at the Washington County line in Bonifay
SR 79 in Bonifay
SR 79 / CR 177A in Bonifay | CR 173 in Bonifay
US 90 (SR 10) / McGee Road in Bonifay
CR 49 at the Alabama state line northwest of Cobb Cross Roads | Former SR 173[1] |
| CR 175}}{{Jct|state=FL|CR|175|county1=Holmes}} | Main Street | SR 2 in Noma | Main Street / Tindell Street in Noma | Former SR 175;[1] Main Street becomes a dirt road north of Tindell Street. |
| CR 177}}{{Jct|state=FL|CR|177|county1=Holmes}} | SR 79 north-northeast of Bonifay | CR 61 at the Alabama state line east-northeast of Smith Crossroads | Former SR 177[1] |
| CR 177A}}{{Jct|state=FL|CR|177A|county1=Holmes}} | West North Avenue
Bonifay–Geneva Highway | SR 79 / CR 173 in Bonifay | CR 53 at the Alabama state line north-northwest of Smith Crossroads | Former SR 177A[1] |
| CR 179}}{{Jct|state=FL|CR|179|county1=Holmes}} | Caryville-Geneva Road | CR 179 at the Washington County line in Caryville | CR 89 at the Alabama state line north-northeast of Pittman | Former SR 179[1] |
| CR 179A}}{{Jct|state=FL|CR|179A|county1=Holmes}} | Pine Street
Hawkins Street
| CR 181 in Westville | CR 33 at the Alabama state line northwest of Pittman | Former SR 179A[1] |
| CR 181}}{{Jct|state=FL|CR|181|county1=Holmes}} | Pine Street
North Cypress Street | CR 181 at the Walton County line southeast of Ponce de Leon | CR 181 at the Walton County line north-northwest of Leonia | Former SR 181[1] |
| CR 181A}}{{Jct|state=FL|CR|181A|county1=Holmes}} | Ponce de Leon Springs Road
Old Mill Road | CR 181A at the Walton County line south-southeast of Ponce de Leon | Old Mill Road in Ponce de Leon | Former SR 181A[1] |
| CR 183A}}{{Jct|state=FL|CR|183A|county1=Holmes}} | CR 10A northwest of Ponce de Leon | CR 183A at the Walton County line south-southwest of Prosperity | Former SR 183A[1] |
| CR 185}}{{Jct|state=FL|CR|185|county1=Holmes}} | Petty Crossroads | CR 185 at the Walton County line south-southwest of Leonia | SR 27 at the Alabama state line east-northeast of Royals Crossroads | Former SR 185[1] (earlier SR 183[2]) |
1. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 {{cite web|url=http://www.dot.state.fl.us/surveyingandmapping/rowmap/d3index/Holmes/Holmes1972.pdf|title=General Highway Map, Holmes County, reprinted April 1972|publisher=Florida Department of Transportation}}
2. ^1 FDOT Right of Way Mapping: Holmes County