| 释义 |
- Type I keratins Human epithelial keratins Human hair keratins Nonhuman hair/epithelial keratins Human keratin pseudogenes
- Type II keratins Human epithelial keratin Human hair keratins Human keratin pseudogenes
- See also
- References
The first sequences of keratins revealed that keratins could be grouped into two categories based on their sequence homologies.[1][2] These two groups of keratins were named as type I and type II keratins.[2] These two categories also represent the first two categories of the superfamily of intermediate filament proteins. Keratins in this table are classified in the first two columns according to the nomenclature established in 2006.[3] Other names previously used are listed in columns 3 and 4. Type I keratinsHuman epithelial keratins| Protein name[3] | Gene name[3] | Other protein name | Other gene name | | K9 | KRT9 | Ka9 | | K10 | KRT10 | Ka10 | | K12 | KRT12 | Ka12 | | K13 | KRT13 | Ka13 | | K14 | KRT14 | Ka14 | | K15 | KRT15 | Ka15 | | K16 | KRT16 | Ka16 | | K17 | KRT17 | Ka17 | | K18 | KRT18 | Ka18 | | K19 | KRT19 | Ka19 | | K20 | KRT20 | Ka20 | | K23 | KRT23 | Ka23 | | K24 | KRT24 | Ka24 | | K25 | KRT25 | Ka38, K25irs1, K10C, hIRSa1 | KRT25A | | K26 | KRT26 | Ka39, K25irs2, K10D | | K27 | KRT27 | Ka40, K25irs3, K10B, hIRSa3.1 | | K28 | KRT28 | Ka41, K25irs4, hIRSa2 |
Human hair keratins| Protein name[3] | Gene name[3] | Other protein name | Other gene name | | K31 | KRT31 | Ka25, Ha1 | KRTHA1 | | K32 | KRT32 | Ka26, Ha2 | KRTHA2 | | K33a | KRT33A | Ka27, Ha3-I | KRTHA3A | | K33b | KRT33B | Ka28, Ha3-II | KRTHA3B | | K34 | KRT34 | Ka29, Ha4 | KRTHA4 | | K35 | KRT35 | Ka30, Ha5 | KRTHA5 | | K36 | KRT36 | Ka31, Ha6 | KRTHA6 | | K37 | KRT37 | Ka32, Ha7 | KRTHA7 | | K38 | KRT38 | Ka33, Ha8 | KRTHA8 | | K39 | KRT39 | Ka35 | | K40 | KRT40 | Ka36 |
Nonhuman hair/epithelial keratins| Protein name[3] | Gene name[3] | Other protein name | Other gene name | | K41 chimp, gorilla | KRT41 chimp, gorilla, KRT41P man | φhHaA, Ka34P man | | K42 mouse, rat | KRT42 mouse, rat, KRT42P man | Ka22 mouse, rat, K17n mouse, rat |
Human keratin pseudogenes| Protein name[3] | Gene name[3] | Other protein name | Other gene name | | KRT221P | φhHaB | | KRT222P | φKRTI, Ka21P | | KRT223P | φKRTJ, Ka37P |
Type II keratinsHuman epithelial keratin| Protein name[3] | Gene name[3] | Other protein name | Other gene name | | K1 | KRT1 | Kb1 | | K2 | KRT2 | Kb2, K2e | KRT2A | | K3 | KRT3 | Kb3 | | K4 | KRT4 | Kb4 | | K5 | KRT5 | Kb5 | | K6a | KRT6A | Kb6 | | K6b | KRT6B | Kb10 | | K7 | KRT7 | Kb7 | | K8 | KRT8 | Kb8 | | K71 | KRT71 | Kb34, K6irs1 | | K72 | KRT72 | Kb35, K6irs2 | | K73 | KRT73 | Kb36, K6irs3 | | K74 | KRT74 | Kb37, K6irs4 | | K75 | KRT75 | Kb18, K6hf | | K76 | KRT76 | Kb9, K2p | KRT2B | | K77 | KRT77 | Kb39, K1b | | K78 | KRT78 | Kb40, K5b | | K79 | KRT79 | Kb38, K6I | | K80 | KRT80 | Kb20 |
Human hair keratins| Protein name[3] | Gene name[3] | Other protein name | Other gene name | | K81 | KRT81 | Kb21, Hb1, K2.9 | KRTHB1 | | K82 | KRT82 | Kb22, Hb2 | KRTHB2 | | K83 | KRT83 | Kb23, Hb3, K2.10 | KRTHB3 | | K84 | KRT84 | Kb24, Hb4 | KRTHB4 | | K85 | KRT85 | Kb25, Hb5, K2.12 | KRTHB5 | | K86 | KRT86 | Kb26, Hb6, K2.11 | KRTHB6 |
Human keratin pseudogenes| Protein name[3] | Gene name[3] | Other protein name | Other gene name | | KRT121P | φhHbD, Kb31P | | KRT122P | φhHbC, Kb30P | | KRT123P | φhHbB, Kb29P | | KRT124P | φhHbA, Kb28P | | KRT125P | φKRTH | | KRT126P | φKRTG, Kb19P | | KRT127P | φKRTF | | KRT128P | φKRTE |
See alsoReferences1. ^{{Cite journal | last1 = Hanukoglu | first1 = I. | last2 = Fuchs | first2 = E. | title = The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins. | journal = Cell | volume = 31 | issue = 1 | pages = 243–52 |date=Nov 1982 | doi = 10.1016/0092-8674(82)90424-X | PMID = 6186381 }}
2. ^1 {{Cite journal | last1 = Hanukoglu | first1 = I. | last2 = Fuchs | first2 = E. | title = The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins. | journal = Cell | volume = 33 | issue = 3 | pages = 915–24 |date=Jul 1983 | doi =10.1016/0092-8674(83)90034-X | PMID = 6191871 }}
3. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 {{cite journal | pmid=16831889 | doi=10.1083/jcb.200603161 | pmc=2064177 | volume=174 | issue=2 | title=New consensus nomenclature for mammalian keratins |date=July 2006 |vauthors=Schweizer J, Bowden PE, Coulombe PA, etal | journal=J. Cell Biol. | pages=169–74}}
2 : Skin anatomy|Keratins |