- Footnotes
- See also
- References
{{see also|List of cutaneous conditions}}{{dynamic list}}Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid. Target antigens for the different pemphigoid variants| Pemphigoid variant | Antibody isotype | Antigen | Molecular weight (KDa) |
|---|
| Bullous pemphigoid | IgG, IgE[1] | NC16A terminal of BPAG2
BPAG1 | 180
230 | | Herpes gestationis | IgG1 | NC16A terminal of BPAG2
BPAG1 | 180
230 | | Cicatricial pemphigoid | C-terminal of BPAG2 | 180 | | Ocular cicatricial pemphigoid | Integrin beta-4 subunit | 200 | | Antiepiligrin cicatricial pemphigoid[2] | Laminin 5 (Epiligrin, Laminin 332) | | Linear IgA bullous dermatosis | LAD1 portion of BPAG2
Collagen type VII
| 97
290/145 | | Protein 105 pemphigoid | Protein in lower lamina lucida | 105 | Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include: Target antigens for the different autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system, excluding pemphigoid| Disease | Antibody isotype | Antigen | Molecular weight (KDa) |
|---|
| Epidermolysis bullosa acquisita | Collagen type VII | 290/145 | | Bullous lupus erythematosus | Collagen type VII | 290/145 | | Lichen planus pemphigoides[3] | BPAG2 | 180 | Footnotes 1. ^http://archderm.jamanetwork.com/article.aspx?articleid=1392581
2. ^The antiepiligrin variant of cicatricial pemphigoid is associated with gastric cancer.
3. ^In this condition bullae develop on skin already affected by lesions of lichen planus as well as on areas of skin without lesions of lichen planus.
See also - List of target antigens in pemphigus
- List of immunofluorescence findings for autoimmune bullous conditions
- List of cutaneous conditions
- List of genes mutated in cutaneous conditions
- List of histologic stains that aid in diagnosis of cutaneous conditions
References - {{cite book |author=Bolognia, Jean L.|title=Dermatology |publisher=Mosby |location=St. Louis |year=2007 |pages= |isbn=1-4160-2999-0 |oclc= |doi= |accessdate=|display-authors=etal}}
- {{cite book |author=James, William D.|title=Andrews' Diseases of the Skin: Clinical Dermatology |publisher=Saunders Elsevier |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |accessdate=|display-authors=etal}}
{{DEFAULTSORT:Target antigens in pemphigoid}} 2 : Cutaneous conditions|Dermatology-related lists |