词条 | Local hormone |
释义 |
Eicosanoids (ī′kō-să-noydz; eicosa = twenty, eidos = formed) are a primary type of local hormone. These local hormones are formed by a chain of 20 amino acids and fatty acids from phospholipids in the cell membrane. Eicosanoids initiate either autocrine stimulation or paracrine stimulation. There are two main types of eicosanoids: prostaglandins and leukotrienes, which initiate either autocrine stimulation Prostaglandins are the most diverse category of eicosanoids and are thought to be synthesized in most tissues of the body. This type of local hormone stimulates pain receptors ClassificationAccording to structural and functional similarity, many local hormones fall into either the gastrin or the secretin family.[6] Gastrin familyThe Gastrin family is a group of peptides evolutionarily similar in structure and function. Commonly synthesized in antroduodenal G-cells. Regulate gastric function along with gastric acid secretion and mucosal growth.[7]
Secretin familyThe Secretin family are peptides that act as local hormones which regulate regulate activity of G-protein coupled receptors. Most often found in the pancreas and the intestines. Secretin was discovered in 1902 by E. H. Starling. It was later linked to chemical regulation and was the first substance to be deemed a hormone.[8]
Others
References1. ^1 2 {{Cite web|url=http://www.uobabylon.edu.iq/eprints/paper_12_19100_806.pdf|title=The Endocrine System 2|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}} 3. Mark H. Whitnall, William G. Haynes, David J. Webb (1997). Principles of Medical Biology.2. ^{{Cite web|url=https://www.biotecharticles.com/Healthcare-Article/Classification-of-Hormones-A-Brief-Study-876.html|title=Classification of Hormones|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}} 3. ^{{Citation|last=Haynes|first=William G.|title=The Endothelins|date=1997|work=Molecular and Cellular Endocrinology|volume=|pages=543–572|publisher=Elsevier|isbn=9781559388153|last2=Webb|first2=David J.|doi=10.1016/s1569-2582(97)80171-7}} 4. ^{{Cite journal|last=Salmon|first=John A|last2=Higgs|first2=Gerald A|date=April 1987|title=Prostaglandins and leukotrienes as inflammatory mediators|journal=British Medical Bulletin|volume=43|issue=2|pages=285–296|doi=10.1093/oxfordjournals.bmb.a072183|issn=1471-8391}} 5. ^1 {{Cite journal|last=Grubb|first=B. J.|date=2006-06-06|title=Developmental Biology, Eighth Edition. Scott F. Gilbert, editor.|journal=Integrative and Comparative Biology|volume=46|issue=5|pages=652–653|doi=10.1093/icb/icl011|issn=1540-7063}} 6. ^{{cite book|last1=Joshi|first1=Vijaya D.|title=Anatomy and Physiology for Nursing and Health Care|date=2006|publisher=BI Publications Pvt Ltd|isbn=9788172252359|page=293|url=https://books.google.com/?id=xCQOf7UrmvcC&dq=Local+hormone+gastrin+secretin|language=en}} 7. ^{{Cite journal|last=Jens F. Rehfeld|last2=Lennart Friis-Hansen|last3=Jens P. Goetze|last4=Thomas V. O. Hansen|date=2007-06-01|title=The Biology of Cholecystokinin and Gastrin Peptides|journal=Current Topics in Medicinal Chemistry|volume=7|issue=12|pages=1154–1165|doi=10.2174/156802607780960483|issn=1568-0266}} 8. ^{{Cite journal|last=J. H. Henriksen, O. B. Schaffalitzk|date=January 2000|title=Secretin, its discovery, and the introduction of the hormone concept|journal=Scandinavian Journal of Clinical and Laboratory Investigation|volume=60|issue=6|pages=463–472|doi=10.1080/003655100448446|issn=0036-5513}} 4. Salmon, John A; Higgs, Gerald A (1987). "Prostaglandins and leukotrienes as inflammatory mediators". British Medical Bulletin. 43 (2): 285–96. PMID 2825898 5. SF Gilbert. (2000). Developmental Biology 6th Edition. 6. Jan M. Keppel Hesselink.(2016). "Autacoids: A New Fundament for Pain Medicine of the 21th Century". 7. a b c d e McKinley, Michael P., et al. Anatomy & Physiology: an Integrative Approach. McGraw-Hill Higher Education, 2012 8. Rehfeld JF1, Friis-Hansen L, Goetze JP, Hansen TV. (2007). "The biology of cholecystokinin and gastrin peptides". Curr Top Med Chem. 2007;7(12):1154-65. 9. Henriksen JH, de Muckadell OB. (2000). "Secretin, its discovery, and the introduction of the hormone concept.". Scand J Clin Lab Invest. 2000 Oct;60(6):463-71. {{Cell signaling}}{{Cell-biology-stub}} 4 : Signal transduction|Hormones|Endocrine system|Cell signaling |
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