| 词条 | Losoxantrone |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = 7-Hydroxy-22-[(2-hydroxyethyl)amino]ethyl5-({2-[(2-hydroxyethyl)amino]ethyl}amino)dibenzo[cd,g]indazol-6(2H)-one | image = Losoxantrone.png | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 88303-60-0 | ATC_prefix = | ATC_suffix = | PubChem = 72116 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 65094 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = | C=22 | H=27 | N=5 | O=4 | molecular_weight = 425.48088 g/mol | smiles = c1cc-2c(c(c1)O)C(=O)c3c(ccc4c3c2nn4CCNCCO)NCCNCCO | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = InChI=1S/C22H27N5O4/c28-12-9-23-6-7-25-15-4-5-16-20-19(15)22(31)18-14(2-1-3-17(18)30)21(20)26-27(16)11-8-24-10-13-29/h1-5,23-25,28-30H,6-13H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = YROQEQPFUCPDCP-UHFFFAOYSA-N }}Losoxantrone (biantrazole) is a anthroquinone anthrapyrazole antineoplastic agent and analog of mitoxantrone.[1][2] It is also sometimes known as DuP 941.[3] See also
References1. ^{{Cite journal | doi = 10.1021/jm00384a021| title = Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias| journal = Journal of Medicinal Chemistry| volume = 30| pages = 121| year = 1987| last1 = Showalter | first1 = H. D. H. | last2 = Johnson | first2 = J. L. | last3 = Hoftiezer | first3 = J. M. | last4 = Turner | first4 = W. R. | last5 = Werbel | first5 = L. M. | last6 = Leopold | first6 = W. R. | last7 = Shillis | first7 = J. L. | last8 = Jackson | first8 = R. C. | last9 = Elslager | first9 = E. F. }} {{Chemotherapeutic agents}}2. ^{{Cite journal | doi = 10.1002/jhet.5570260117| title = Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride| journal = Journal of Heterocyclic Chemistry| volume = 26| pages = 85| year = 1989| last1 = Beylin | first1 = V. G. | last2 = Colbry | first2 = N. L. | last3 = Goel | first3 = O. P. | last4 = Haky | first4 = J. E. | last5 = Johnson | first5 = D. R. | last6 = Johnson | first6 = J. L. | last7 = Kanter | first7 = G. D. | last8 = Leeds | first8 = R. L. | last9 = Leja | first9 = B. | last10 = Lewis | first10 = E. P. | last11 = Rithner | first11 = C. D. | last12 = Showalter | first12 = H. D. H. | last13 = Sercel | first13 = A. D. | last14 = Turner | first14 = W. R. | last15 = Uhlendorf | first15 = S. E. }} 3. ^{{cite journal|last1=Leteurtre|first1=F.|last2=Kohlhagen|first2=G.|last3=Paull|first3=K. D.|last4=Pommier|first4=Y.|title=Topoisomerase II Inhibition and Cytotoxicity of the Anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute Preclinical Antitumor Drug Discovery Screen|journal=JNCI Journal of the National Cancer Institute|date=17 August 1994|volume=86|issue=16|pages=1239–1244|doi=10.1093/jnci/86.16.1239}} 7 : Antineoplastic drugs|Topoisomerase inhibitors|Amines|Alcohols|Nitrogen heterocycles|Heterocyclic compounds (4 or more rings)|Hydroxyarenes |
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