| 词条 | LP-12 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 449684539 | IUPAC_name = 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide | image = LP-12_structure.png | width = 240 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 23643664 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 22439715 | C=32 | H=39 | N=3 | O=1 | molecular_weight = 481.670 g/mol | smiles = C5CCc1ccccc1C5NC(=O)CCCCCN3CCN(CC3)c2ccccc2-c4ccccc4 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C32H39N3O/c36-32(33-30-18-11-15-26-14-6-7-16-28(26)30)20-5-2-10-21-34-22-24-35(25-23-34)31-19-9-8-17-29(31)27-12-3-1-4-13-27/h1,3-4,6-9,12-14,16-17,19,30H,2,5,10-11,15,18,20-25H2,(H,33,36) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = NMZIDFFHGCRAJV-UHFFFAOYSA-N }}LP-12 is a drug which acts as a potent agonist at the 5HT7 serotonin receptor, with very high selectivity over other tested receptor subtypes such as the serotonin 5-HT1A and 5-HT2A, and the dopamine D2 receptor. It has been used to research the involvement of the 5-HT7 receptor in as yet poorly understood processes such as allodynia and hyperalgesia.[1] See also
References1. ^{{cite journal |vauthors=Godínez-Chaparro B, Barragán-Iglesias P, Castañeda-Corral G, Rocha-González HI, Granados-Soto V |title=Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia |journal=Pain |volume=152 |issue=3 |pages=687–97 |date=March 2011 |pmid=21239110 |doi=10.1016/j.pain.2010.12.020 |url=}} {{Serotonergics}}{{Piperazines}} 2 : Serotonin receptor agonists|Piperazines |
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