Malate dehydrogenase is an enzyme that reversibly catalyzes the oxidation of malate to oxaloacetate using the reduction of NAD+ to NADH.

Malate dehydrogenase may also refer to:

• Malate dehydrogenase (decarboxylating) or NAD-malic enzyme
• Malate dehydrogenase (NADP⁺)
• Malate dehydrogenase (oxaloacetate-decarboxylating), another NAD-malic enzyme
• Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP⁺) or NADP-malic enzyme
• Malate dehydrogenase (quinone)

and

• D-malate dehydrogenase (decarboxylating)

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