Matthew Thornton was a signer of the US Declaration of Independence.

Matthew Thornton or Matt Thornton may also refer to:

• Matt Thornton (baseball) (born 1976), Major League Baseball relief pitcher
• Matt Thornton (martial artist) (born 1969), martial artist and founder of Straight Blast Gym
• Matthew Thornton Elementary School
• Matthew Thornton House
• SS Matthew Thornton, see List of Liberty ships
• Matthew Thornton, Sr., see Beale Street
• Matthew Thornton, mayor of Lambton, New South Wales

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