| 词条 | Megestrol |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 462101940 | IUPAC_name = 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione | image = Megestrol.svg | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 3562-63-8 | CAS_supplemental = | ATC_prefix = None | ATC_suffix = | PubChem = 1909019090 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 18023 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 6722 | C=22 | H=30 | O=3 | molecular_weight = 342.472 g/mol | smiles = O=C4\\C=C3\\C(=C/[C@@H]1[C@H](CC[C@@]2([C@@](O)(C(=O)C)CC[C@@H]12)C)[C@@]3(C)CC4)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18+,20-,21+,22+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = VXIMPSPISRVBPZ-NWUMPJBXSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_category = | legal_status = | routes_of_administration = }}Megestrol ({{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|BAN|British Approved Name}}) is a progestin of the 17α-hydroxyprogesterone group which was never marketed and is not currently used clinically.[1][2] Its acylated derivative megestrol acetate is also a progestogen, which, in contrast to megestrol itself, has been extensively used as a pharmaceutical drug.[1][2] SynthesisSee also
References1. ^1 {{cite book | author = F.. Macdonald | title = Dictionary of Pharmacological Agents | url = https://books.google.com/books?id=A0THacd46ZsC&pg=PA1267 | accessdate = 12 May 2012 | year = 1997 | publisher = CRC Press | isbn = 978-0-412-46630-4 | page = 1267}} {{Progesterone receptor modulators}}{{Steroid-stub}}{{Genito-urinary-drug-stub}}2. ^1 {{cite book | title = Index Nominum 2000: International Drug Directory | url = https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA641 | accessdate = 28 May 2012 | year = 2000 | publisher = Taylor & Francis US | isbn = 978-3-88763-075-1 | page = 641}} 3. ^{{Cite journal | last1 = Ringold | first1 = H. J. | title = Steroids. CXVIII.16-Methyl Derivatives of 17α-Hydroxyprogesterone and of Reichstein's Substance "S" | last2 = Ruelas | first2 = J. P. | last3 = Batres | first3 = E. | last4 = Djerassi | first4 = C. | journal = Journal of the American Chemical Society | volume = 81 | issue = 14 | pages = 3712 | year = 1959 | doi = 10.1021/ja01523a055}} 5 : Alcohols|Dienes|Diketones|Pregnanes|Progestogens |
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