| 词条 | Messenger RNP |
| 释义 |
When mRNA is being synthesized by RNA polymerase, this nascent mRNA is already bound by RNA 5′ end 7-methyl-guanosine capping enzymes. Later, the pre-mRNA is bound by the spliceosome containing exon and intron definition complexes and proteins and RNA that catalyze the chemical reactions of splicing. Joan Steitz and Michael Lerner and collaborators showed that the small nuclear RNAs (snRNAs) are complexed into small nuclear Ribonuclear Proteins (snRNPs).[3] Christine Guthrie and collaborators showed that specific snRNAs encoded by single copy genes in yeast base pair with the pre-mRNA and direct each step in splicing.[2] The spliced mRNA is bound by another set of proteins which help in export from the nucleus to the cytoplasm. In vertebrates exon-exon junction are marked by exon junction complexes which in the cytosol can trigger nonsense mediated decay if the exon-exon junction is more than 50-55 nt downstream of the stop codon.[4] See also
References1. ^{{Cite journal| doi = 10.1101/gad.1256904| issn = 0890-9369| volume = 18| issue = 23| pages = 2845–2860| last = Hieronymus| first = Haley|author2=Pamela A. Silver| title = A systems view of mRNP biology| journal = Genes & Development| accessdate = 2013-07-24| date = 2004-12-01| url = http://genesdev.cshlp.org/content/18/23/2845| pmid=15574591}} {{biochem-stub}}2. ^1 {{Cite journal| doi = 10.1016/j.cell.2009.01.047| issn = 0092-8674| volume = 136| issue = 4| pages = 794-794.e1| last = Bergkessel| first = Megan|author2=Gwendolyn M. Wilmes |author3=Christine Guthrie | title = SnapShot: Formation of mRNPs| journal = Cell| accessdate = 2013-07-24| date = 2009-02-20| url = http://www.sciencedirect.com/science/article/pii/S0092867409001305 | pmid=19239896}} 3. ^Michael Lerner, JA Boyle, SM Mount, Sandra Wolin and Joan Steitz 1980 "Are snRNPs involved in splicing?" Nautre 283 (5743): 220-4. doi:10.1038/283220q0 4. ^{{Cite journal|last=Lykke-Andersen|first=Søren|last2=Jensen|first2=Torben Heick|date=2015-09-23|title=Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes|url=http://www.nature.com/doifinder/10.1038/nrm4063|journal=Nature Reviews Molecular Cell Biology|language=en|volume=16|issue=11|pages=665–677|doi=10.1038/nrm4063|issn=1471-0080}} 2 : RNA|Protein complexes |
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