| 词条 | Methyldibromo glutaronitrile |
| 释义 |
| ImageFile = MDBGN.png | ImageSize = | ImageAlt = Structural formula of methyldibromo glutaronitrile | IUPACName = 2-Bromo-2-(bromomethyl)-pentanedinitrile | OtherNames = 1,2-Dibromo-2,4-dicyanobutane 1-Bromo-1-(bromomethyl)-1,3-propanedicarbonitrile 2-Bromo-2-(bromomethyl) glutaronitrile 2-Bromo-2-(bromomethyl)pentanedinitrile Bromothalonil Euxyl K400 Tektamer 38 Merquat 2200 Metacide 38 |Section1={{Chembox Identifiers | CASNo = 35691-65-7 | PubChem = 61948 | SMILES = C(CC(CBr)(C#N)Br)C#N | EINECS = 252-681-0 | ChemSpiderID = 55806 | InChI = 1/C6H6Br2N2/c7-4-6(8,5-10)2-1-3-9/h1-2,4H2 | InChIKey = DHVLDKHFGIVEIP-UHFFFAOYAK | StdInChI = 1S/C6H6Br2N2/c7-4-6(8,5-10)2-1-3-9/h1-2,4H2 | StdInChIKey = DHVLDKHFGIVEIP-UHFFFAOYSA-N | RTECS = | MeSHName = | ChEBI = 62823}} |Section2={{Chembox Properties | C=6 | H=6 | Br=2 | N=2 | Appearance = White to yellow crystals | Density = | MeltingPtC = 51.2 to 52.5 | MeltingPt_notes = | BoilingPtC = 212 | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} Methyldibromo glutaronitrile (MDBGN) is a widely used preservative. It is made by reacting bromine with 2-methyleneglutaronitrile below 30 °C. An allergy to the chemical can be discovered by performing a patch test. History and allergyIn the mid-1980s, a maximum concentration of 0.1% in stay-on and rinse-off cosmetics was allowed.[1] It was discovered soon afterwards that it caused allergic contact dermatitis to people with eczema.[1] It has been in use since the 1990s as a preservative in skin care products such as lotions, wet wipes, shampoo, and liquid soaps. Industrial applications include its use in preserving oils, glues, and medical gels.[2] In 2005, the EU banned its use in stay-on products,[3] and in 2007 banned it in rinse-off products.[1] In 2005–06, methyldibromoglutaronitrile/ phenoxyethanol was the ninth-most-prevalent allergen in patch tests]] (5.8%).[4] References1. ^1 2 {{cite web | url=http://dermnetnz.org/dermatitis/methyldibromo-glutaronitrile.html | title=Allergy to methyldibromo glutaronitrile | work=DermNet NZ | accessdate=21 September 2013 | author=Ngan, Vanessa}} 2. ^{{cite web|url=http://www.dermnetnz.org/dermatitis/methyldibromo-glutaronitrile.html |title=Allergy to methyldibromo glutaronitrile |publisher=Dermnetnz.org |date=2014-01-20 |accessdate=2014-04-09}} 3. ^{{cite book|author1=Jeanne Duus Johansen|author2=Peter J. Frosch|author3=Jean-Pierre Lepoittevin|title=Contact Dermatitis|url=https://books.google.com/books?id=sSHIlWSOiroC&pg=PA575|accessdate=21 September 2013|date=29 September 2010|publisher=Springer|isbn=978-3-642-03827-3|page=575}} 4. ^Zug KA, Warshaw EM, Fowler JF Jr, Maibach HI, Belsito DL, Pratt MD, Sasseville D, Storrs FJ, Taylor JS, Mathias CG, Deleo VA, Rietschel RL, Marks J. Patch-test results of the North American Contact Dermatitis Group 2005–2006. Dermatitis. 2009 May–Jun;20(3):149-60. External links
3 : Preservatives|Nitriles|Organobromides |
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