Michael O'Donnell may refer to:

• Michael O'Donnell (physician) (born 1928), British physician, journalist, author, and broadcaster
• Michael O'Donnell (politician) (born 1984), Kansas politician
• Michael A. O'Donnell (born 1956), American author, researcher, and lecturer
• Michael O'Donnell (rugby league), New Zealand former professional rugby league footballer
• Mike O'Donnell, main character in the film 17 Again

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