Michael or Mike O'Rourke is the name of:

• Michael O'Rourke (gambler) (1862–1882, alias "Johnny-Behind-the-Deuce"), professional gambler of the Old West
• Michael James O'Rourke (1878–1957), Canadian recipient of the Victoria Cross
• Mike O'Rourke (baseball) (1868-1934), Major League Baseball pitcher
• Mike O'Rourke (athlete) (born 1955), New Zealand javelin thrower
• Michael S. O'Rourke, writer and actor

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