| 词条 | Michael R. Gold |
| 释义 |
| name = Michael R. Gold | image = | image_size = | alt = | caption = | birth_date = {{Birth date and age|1956|08|30}} | birth_place = United States | death_date = | death_place = | resting_place = | resting_place_coordinates = | residence = Vancouver, British Columbia, Canada | citizenship = Canadian | nationality = Canadian | fields = Biology Immunology Cell Biology | workplaces = University of British Columbia | alma_mater = Michigan State University University of California, Berkeley University of California, San Francisco | doctoral_advisor = | academic_advisors = Robert I. Mishell Anthony DeFranco Ruedi Aebersold | doctoral_students = | notable_students = | known_for = Discovery of B-cell receptor stimulates Tyrosine phosphorylation | author_abbrev_bot = | author_abbrev_zoo = | influences = | influenced = | awards = | signature = | signature_alt = | website = | footnotes = | spouse = Linda Matsuuchi }} Michael R. Gold, (born August 30, 1956 in New York City, USA) is a Canadian immunologist and cell biologist, head of Head, UBC Department of Microbiology and Immunology, at the University of British Columbia July 2009. He is known for his discovery of how B-cell receptor stimulates Tyrosine phosphorylation and work in the signaling cascade of B-cell receptor. Biography lifeBorn and raised in New York City, New York, USA in 1956. He attended the John Bowne High School in Flushing, New York. and then Michigan State University. He was a graduate student at the University of California, Berkeley from 1978-1984, under the supervision of Robert I. Mishell. The goal of his Ph.D. project was to characterize biochemically a receptor present on macrophages, that recognize bacterial peptidoglycan. He then entered a postdoctoral fellowship at the University of California, San Francisco (1985-1991) working on B-cell signalling with Anthony DeFranco, followed by a position as research associate in Ruedi Aebersold’s lab at the Institute for Systems Biology in Seattle, Washington, (1991-1993) His work led to many important findings, emphasizing the importance of how antigen receptors on the surface of B-cells might trigger the adaptive immunity upon recognizing their cognate antigens Over a decade, his laboratory has been intensely focusing on how the roles of Rap GTPases in mediating cell mobility, cell migration, tumor motility and metastasis. He is interested in how changes in cytoskeletal structure and function by Rap may affect B-cell receptor activation and signalling cascade. Gold’s publications have been cited more than 6,200 times with the [h-index] of 42. He is a faculty member of the Department of Microbiology and Immunology at the University of British Columbia, He has been Head of the Department of Microbiology and Immunology since July 2009. He currently also teaches MICB 502 (Advanced Immunogenetics) in the Department of Microbiology and Immunology at the University of British Columbia. Fellowships and awards
Editorships
Leadership
ReferencesMost Significant Contributions
| pmid = 1694265 | year = 1990 | author1 = Gold | first1 = M. R. | title = Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor | journal = Nature | volume = 345 | issue = 6278 | pages = 810–3 | last2 = Law | first2 = D. A. | last3 = Defranco | first3 = A. L. | doi = 10.1038/345810a0 }}
| pmid = 19843950 | year = 2009 | author1 = Durand | first1 = C. A. | title = Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses | journal = The Journal of Immunology | volume = 183 | issue = 9 | pages = 5673–84 | last2 = Hartvigsen | first2 = K | last3 = Fogelstrand | first3 = L | last4 = Kim | first4 = S | last5 = Iritani | first5 = S | last6 = Vanhaesebroeck | first6 = B | last7 = Witztum | first7 = J. L. | last8 = Puri | first8 = K. D. | last9 = Gold | first9 = M. R. | doi = 10.4049/jimmunol.0900432 }}
| pmid = 18191594 | year = 2008 | author1 = Lin | first1 = K. B. | title = The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands | journal = Immunity | volume = 28 | issue = 1 | pages = 75–87 | last2 = Freeman | first2 = S. A. | last3 = Zabetian | first3 = S | last4 = Brugger | first4 = H | last5 = Weber | first5 = M | last6 = Lei | first6 = V | last7 = Dang-Lawson | first7 = M | last8 = Tse | first8 = K. W. | last9 = Santamaria | first9 = R | last10 = Batista | first10 = F. D. | last11 = Gold | first11 = M. R. | doi = 10.1016/j.immuni.2007.11.019 }}
| pmid = 12133960 | year = 2002 | author1 = McLeod | first1 = S. J. | title = The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): Potential role for Rap2 in promoting B cell migration | journal = Journal of Immunology | volume = 169 | issue = 3 | pages = 1365–71 | last2 = Li | first2 = A. H. | last3 = Lee | first3 = R. L. | last4 = Burgess | first4 = A. E. | last5 = Gold | first5 = M. R. | doi=10.4049/jimmunol.169.3.1365 }}
| pmid = 22068232 | year = 2011 | author1 = Freeman | first1 = S. A. | title = Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation | journal = The Journal of Immunology | volume = 187 | issue = 11 | pages = 5887–900 | last2 = Lei | first2 = V | last3 = Dang-Lawson | first3 = M | last4 = Mizuno | first4 = K | last5 = Roskelley | first5 = C. D. | last6 = Gold | first6 = M. R. | doi = 10.4049/jimmunol.1102233 }}
External links
5 : 1956 births|Living people|Canadian biologists|Canadian immunologists|University of British Columbia faculty |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。