| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}MicroRNA 196a-2 is a MicroRNA that in humans is encoded by the MIR196A2 gene,[1] and is part of the Mir-196 microRNA precursor family. Function microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. References 1. ^{{cite web | title = Entrez Gene: MicroRNA 196a-2 | url = https://www.ncbi.nlm.nih.gov/gene/406973 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Park YS, Jeon YJ, Lee BE, Kim TG, Choi JU, Kim DS, Kim NK | title = Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population | journal = Neuroscience Letters | volume = 521 | issue = 1 | pages = 71–5 | date = July 2012 | pmid = 22659075 | doi = 10.1016/j.neulet.2012.05.062 }}
- {{cite journal | vauthors = Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP | title = Vertebrate microRNA genes | journal = Science | volume = 299 | issue = 5612 | pages = 1540 | date = March 2003 | pmid = 12624257 | pmc = | doi = 10.1126/science.1080372 }}
- {{cite journal | vauthors = Qi P, Dou TH, Geng L, Zhou FG, Gu X, Wang H, Gao CF | title = Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection | journal = Human Immunology | volume = 71 | issue = 6 | pages = 621–6 | date = June 2010 | pmid = 20188135 | doi = 10.1016/j.humimm.2010.02.017 }}
- {{cite journal | vauthors = Dou T, Wu Q, Chen X, Ribas J, Ni X, Tang C, Huang F, Zhou L, Lu D | title = A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population | journal = Journal of Cancer Research and Clinical Oncology | volume = 136 | issue = 12 | pages = 1853–9 | date = December 2010 | pmid = 20229273 | doi = 10.1007/s00432-010-0844-5 }}
- {{cite journal | vauthors = Mori M, Nakagami H, Rodriguez-Araujo G, Nimura K, Kaneda Y | title = Essential role for miR-196a in brown adipogenesis of white fat progenitor cells | journal = PLoS Biology | volume = 10 | issue = 4 | pages = e1001314 | year = 2012 | pmid = 22545021 | pmc = 3335871 | doi = 10.1371/journal.pbio.1001314 }}
- {{cite journal | vauthors = Ye Y, Wang KK, Gu J, Yang H, Lin J, Ajani JA, Wu X | title = Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk | journal = Cancer Prevention Research | volume = 1 | issue = 6 | pages = 460–9 | date = November 2008 | pmid = 19138993 | pmc = 2768267 | doi = 10.1158/1940-6207.CAPR-08-0135 }}
- {{cite journal | vauthors = Qiu LX, Wang Y, Xia ZG, Xi B, Mao C, Wang JL, Wang BY, Lv FF, Wu XH, Hu LQ | title = miR-196a2 C allele is a low-penetrant risk factor for cancer development | journal = Cytokine | volume = 56 | issue = 3 | pages = 589–92 | date = December 2011 | pmid = 21907588 | doi = 10.1016/j.cyto.2011.08.019 }}
- {{cite journal | vauthors = Kashiyama K, Mitsutake N, Matsuse M, Ogi T, Saenko VA, Ujifuku K, Utani A, Hirano A, Yamashita S | title = miR-196a downregulation increases the expression of type I and III collagens in keloid fibroblasts | journal = The Journal of Investigative Dermatology | volume = 132 | issue = 6 | pages = 1597–604 | date = June 2012 | pmid = 22358059 | doi = 10.1038/jid.2012.22 }}
- {{cite journal | vauthors = Xu W, Xu J, Liu S, Chen B, Wang X, Li Y, Qian Y, Zhao W, Wu J | title = Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: a meta-analysis | journal = PLoS One | volume = 6 | issue = 5 | pages = e20471 | year = 2011 | pmid = 21637771 | pmc = 3102728 | doi = 10.1371/journal.pone.0020471 }}
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