请输入您要查询的百科知识：

　

词条 Migration inducting gene 7
释义

  1. Expression

  2. Function and role in cancer

  3. Targeting of Mig-7

  4. References

{{Orphan|date=March 2018}}{{expert needed|1=Genetics|date=February 2014}}{{Infobox_gene}}Migration inducting gene 7 (Mig-7 or Mig7) is a gene. The protein is cysteine-rich, and localized to the cell membrane and cytoplasm.[1] It is the first-in-class of novel proteins translated from what are thought to be long Non-coding RNAs.[2]

Induction of Mig-7 expression occurs downstream of Epidermal growth factor/Epidermal growth factor receptor, Cox-2/PGE-2 or Hepatocyte growth factor/c-Met activation and signalling.[3][4][5] Data has shown that Mig-7 expression is specific to human embryonic/fetal cytotrophoblast cells[4][6] and epithelial type cancer cells, while not expressed in normal cells.[3][4][5][6][7][8][9] Data demonstrate that targeting of Mig-7 simultaneously inhibits more than one cancer-progressing pathway while likely sparing normal cells.[3][4][5][6][9][10]

Expression

Mig-7 expression is found on, as well as in, epithelial tumor cells at the primary site, secondary (metastatic) sites, and blood from cancer patients. It is not produced by cells of normal human tissues or by cells from patients with inflammation but is expressed by epithelial precancerous and malignant cells.[3][4][5][9] It is also expressed in fetal/embryonic cytotrophoblast cells of early placenta.[4][6]

Mig-7 expression increases in malignant cancers. There is a high sensitivity and specificity of Mig-7 detection in breast (98% n=48 of 49), uterine (100% n=49), gastric (94.5% n=104 of 110) and lung (100% n=89) cancers.[3][5][8][9]

Function and role in cancer

Mig-7 is thought to promote carcinoma cell invasion, metastasis and tumor growth through vasculogenic mimicry,[10] a process where tumor cells form channels for fluids to flow through.[11] It also promotes epithelial–mesenchymal transition (EMT), a key developmental program that is often activated during, and required for, cancer invasion/metastasis. Mig-7 induces EMT through hyperactivation of Akt and extracellular regulated Kinase ERK1/2 by inhibiting the tumor suppressor protein phosphate 2A.[3][5][12]

Mig-7 has been associated with signaling pathways downstream of epithelial type cancer-promoting kinases. It is expressed prior to TWIST,[13] the previously named “master regulator” of EMT.[14] It has also been shown to promote tumor neovascularization.[4][7][8][10]

Cancer cell metabolism (also known as oxidative glycolysis or the Warburg effect) is a proposed cancer target and is likely regulated by Mig-7 through its hyperactivation of Akt.[5]

Targeting of Mig-7

Targeting of Mig-7 with Mig-7-specific peptides significantly stimulates breast cancer patients’ immune cells’ killing of breast carcinoma cells ex vivo.[5] Targeting with antibody generated to the peptide representing the first nine amino acids of Mig-7 detects cells expressing this protein and significantly inhibits carcinoma cell invasion in vitro. Targeting with short hairpin RNA, specific to decrease Mig-7 protein levels, inhibits carcinoma cell invasion and metastasis as well as returns ERK1/2, Akt, GSK, and S6 kinase to normal phosphorylation states through reactivation of PP2A.[3][4][5]

References

1. ^{{cite journal |title= Mig-7 Linked to Vasculogenic Mimicry |author= Robertson, G. P. |journal= Am J Pathol |date= May 2007 |volume=170 |issue=5 |pages= 1454–1456 |doi= 10.2353/ajpath.2007.070127|pmc= 1854941 }}
2. ^{{cite journal |vauthors=Petty AP, Dick CL, Lindsey JS |title= Translation of an atypical human cDNA requires fidelity of apurine-pyrimidine repeat region and recoding |journal = Gene |volume= 414 |issue= 1-2 |pages= 49–59 |date= May 2008 |pmid= 18378409 |doi= 10.1016/j.gene.2008.02.006 }}
3. ^1 2 3 4 5 6 {{cite journal |vauthors=Ho MY, Liang SM, Hung SW, Liang CM | title = MIG-7 controls COX-2/PGE2-mediated lung cancer metastasis | journal = Cancer Res. | volume = 73 | issue = 1 | pages = 439–49 |date=January 2013 | pmid = 23149922 | doi = 10.1158/0008-5472.CAN-12-2220 }}
4. ^1 2 3 4 5 6 7 {{cite journal |vauthors=Petty AP, Garman KL, Winn VD, Spidel CM, Lindsey JS | title = Overexpression of carcinoma and embryonic cytotrophoblast cell-specific Mig-7 induces invasion and vessel-like structure formation | journal = Am. J. Pathol. | volume = 170 | issue = 5 | pages = 1763–80 |date=May 2007 | pmid = 17456780 | pmc = 1854969 | doi = 10.2353/ajpath.2007.060969 }}
5. ^1 2 3 4 5 6 7 8 {{cite journal |vauthors=Petty AP, Wright SE, Rewers-Felkins KA, Yenderrozos MA, Vorderstrasse BA, Lindsey JS | title = Targeting migration inducting gene-7 inhibits carcinoma cell invasion, early primary tumor growth, and stimulates monocyte oncolytic activity | journal = Mol. Cancer Ther. | volume = 8 | issue = 8 | pages = 2412–23 |date=August 2009 | pmid = 19671748 | pmc = 2728173 | doi = 10.1158/1535-7163.MCT-09-0186 }}
6. ^1 2 3 {{cite journal |vauthors=Crouch S, Spidel CS, Lindsey JS | title = HGF and ligation of alphavbeta5 integrin induce a novel, cancer cell-specific gene expression required for cell scattering | journal = Exp. Cell Res. | volume = 292 | issue = 2 | pages = 274–87 |date=January 2004 | pmid = 14697335 | doi = 10.1016/j.yexcr.2003.09.016 }}
7. ^1 {{cite journal |vauthors=Li WL, Gao Q | title = [Mig-7 enhances vasculogenic mimicry in gastric cancer cells] | language = Chinese | journal = Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | volume = 28 | issue = 11 | pages = 1142–5 |date=November 2012 | pmid = 23127401 | doi = }}
8. ^1 2 {{cite journal |vauthors=Liao S, Gao Q | title = [Expressions and clinical significance of vasculogenic mimicry and related protein Mig-7 and MMP-2 in gastric carcinoma] | language = Chinese | journal = Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | volume = 29 | issue = 2 | pages = 194–6 |date=February 2013 | pmid = 23388341 | doi = }}
9. ^1 2 3 {{cite journal |vauthors=Phillips TM, Lindsey JS | title = Carcinoma cell-specific Mig-7: a new potential marker for circulating and migrating cancer cells | journal = Oncol. Rep. | volume = 13 | issue = 1 | pages = 37–44 |date=January 2005 | pmid = 15583799 | doi = 10.3892/or.13.1.37}}
10. ^1 2 {{cite journal | author = Robertson GP | title = Mig-7 linked to vasculogenic mimicry | journal = Am. J. Pathol. | volume = 170 | issue = 5 | pages = 1454–6 |date=May 2007 | pmid = 17456752 | pmc = 1854941 | doi = 10.2353/ajpath.2007.070127 }}
11. ^{{cite journal |vauthors=Folberg R, Maniotis AJ | title = Vasculogenic mimicry | journal = APMIS | volume = 112 | issue = 7-8 | pages = 508–25 | year = 2004 | pmid = 15563313 | doi = 10.1111/j.1600-0463.2004.apm11207-0810.x }}
12. ^{{cite journal |vauthors=Weiss MB, Abel EV, Mayberry MM, Basile KJ, Berger AC, Aplin AE | title = TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells | journal = Cancer Res. | volume = 72 | issue = 24 | pages = 6382–92 |date=December 2012 | pmid = 23222305 | pmc = 3531871 | doi = 10.1158/0008-5472.CAN-12-1033 }}
13. ^{{cite journal |vauthors=Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA | title = The epithelial-mesenchymal transition generates cells with properties of stem cells | journal = Cell | volume = 133 | issue = 4 | pages = 704–15 |date=May 2008 | pmid = 18485877 | pmc = 2728032 | doi = 10.1016/j.cell.2008.03.027 }}
14. ^{{cite journal |vauthors=Zheng H, Kang Y | title = Multilayer control of the EMT master regulators | journal = Oncogene | volume = 33| issue = 14| pages = 1755–63|date=April 2013 | pmid = 23604123 | doi = 10.1038/onc.2013.128 }}

2 : Genes|Oncogenes
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/12 6:00:25