| 词条 | MiR-144 |
| 释义 |
| Name = miR-144 | image =Mir-144 SS.png | width = | caption = Conserved secondary structure of miR-144 precursor microRNA | Symbol = miR-144 | AltSymbols = MIR144 | Rfam = RF00682 | miRBase = MI0000460 | miRBase_family = MIPF0000093 | RNA_type = miRNA | Tax_domain = Mammalia | GO = 0035195 | SO = 0001244 | CAS_number = | EntrezGene = 406936 | HGNCid = 31531 | OMIM = 612070 | PDB = | RefSeq = NR_029685 | Chromosome = 17 | Arm = q | Band = 11.2 | LocusSupplementaryData = }} {{lowercase}} __NOTOC__ miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] In humans, miR-144 has been characterised as a "common miRNA signature"[2] of a number of different tumours. GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[3]FunctionmiR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[4] One of the identified targets of miR-144 is insulin receptor substrate 1.[5] ApplicationsmiR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[3] References1. ^{{cite journal | vauthors = Ambros V | title = microRNAs: tiny regulators with great potential | journal = Cell | volume = 107 | issue = 7 | pages = 823–6 | date = Dec 2001 | pmid = 11779458 | doi = 10.1016/S0092-8674(01)00616-X }} 2. ^{{cite journal | vauthors = Wang W, Peng B, Wang D, Ma X, Jiang D, Zhao J, Yu L | title = Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets | journal = International Journal of Cancer | volume = 129 | issue = 7 | pages = 1624–34 | date = Oct 2011 | pmid = 21128228 | doi = 10.1002/ijc.25818 }} 3. ^1 {{cite journal | vauthors = Zhang X, Wang X, Zhu H, Zhu C, Wang Y, Pu WT, Jegga AG, Fan GC | title = Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death | journal = Journal of Molecular and Cellular Cardiology | volume = 49 | issue = 5 | pages = 841–50 | date = Nov 2010 | pmid = 20708014 | pmc = 2949485 | doi = 10.1016/j.yjmcc.2010.08.007 }} 4. ^{{cite journal | vauthors = Rasmussen KD, Simmini S, Abreu-Goodger C, Bartonicek N, Di Giacomo M, Bilbao-Cortes D, Horos R, Von Lindern M, Enright AJ, O'Carroll D | title = The miR-144/451 locus is required for erythroid homeostasis | journal = The Journal of Experimental Medicine | volume = 207 | issue = 7 | pages = 1351–8 | date = Jul 2010 | pmid = 20513743 | pmc = 2901075 | doi = 10.1084/jem.20100458 }} 5. ^{{cite journal | vauthors = Karolina DS, Armugam A, Tavintharan S, Wong MT, Lim SC, Sum CF, Jeyaseelan K | title = MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus | journal = PLOS ONE | volume = 6 | issue = 8 | pages = e22839 | year = 2011 | pmid = 21829658 | pmc = 3148231 | doi = 10.1371/journal.pone.0022839 }} 6. ^{{cite journal | vauthors = Dinan TG | title = MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field | journal = The International Journal of Neuropsychopharmacology | volume = 13 | issue = 3 | pages = 395–404 | date = Apr 2010 | pmid = 19849891 | doi = 10.1017/S1461145709990800 }}{{subscription}} Further reading{{refbegin}}
External links
1 : MicroRNA |
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