词条 | MiR-150 |
释义 |
| Name = miR-150 | image =Mir-150 SS.png | width = | caption = Conserved secondary structure of miR-150 microRNA precursor | Symbol = miR-150 | AltSymbols = MIR150 | Rfam = RF00767 | miRBase = MI0000479 | miRBase_family = MIPF0000197 | RNA_type = miRNA | Tax_domain = Mammalia | GO = 0035195 | SO = 0001244 | CAS_number = | EntrezGene = 406942 | HGNCid = 31537 | OMIM = 610566 | PDB = | RefSeq = NR_029703 | Chromosome = 19 | Arm = q | Band = 13.33 | LocusSupplementaryData = }} {{lowercase}} __NOTOC__ miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]miR-150 functions in hematopoiesis; it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes.[3][4] It is also thought to control B and T cell differentiation, alongside mir-155.[5][6] Role in cancermiR-150 has been linked with a number of cancers. It is thought to promote cancer cell proliferation in gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma.[7] ApplicationsmiR-150 levels in blood plasma can be indicative of early sepsis; it could have a future use therapeutically in treating the condition.[8] In addition, miR-150 is one of a number of microRNAs whose expression profile could be used as a biomarker of hepatocellular carcinoma.[9] References1. ^{{cite journal | vauthors = Ambros V | title = microRNAs: tiny regulators with great potential | journal = Cell | volume = 107 | issue = 7 | pages = 823–6 | date = Dec 2001 | pmid = 11779458 | doi = 10.1016/S0092-8674(01)00616-X }} 2. ^{{cite journal | vauthors = Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R | title = Human RISC couples microRNA biogenesis and posttranscriptional gene silencing | journal = Cell | volume = 123 | issue = 4 | pages = 631–40 | date = Nov 2005 | pmid = 16271387 | doi = 10.1016/j.cell.2005.10.022 }} 3. ^{{cite journal | vauthors = Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR | title = MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors | journal = Developmental Cell | volume = 14 | issue = 6 | pages = 843–53 | date = Jun 2008 | pmid = 18539114 | pmc = 2688789 | doi = 10.1016/j.devcel.2008.03.012 }} 4. ^{{cite journal | vauthors = Edelstein LC, Bray PF | title = MicroRNAs in platelet production and activation | journal = Blood | volume = 117 | issue = 20 | pages = 5289–96 | date = May 2011 | pmid = 21364189 | pmc = 3109704 | doi = 10.1182/blood-2011-01-292011 }} 5. ^{{cite journal | vauthors = Vasilatou D, Papageorgiou S, Pappa V, Papageorgiou E, Dervenoulas J | title = The role of microRNAs in normal and malignant hematopoiesis | journal = European Journal of Haematology | volume = 84 | issue = 1 | pages = 1–16 | date = Jan 2010 | pmid = 19744129 | doi = 10.1111/j.1600-0609.2009.01348.x }} 6. ^{{cite journal | vauthors = Garzon R, Croce CM | title = MicroRNAs in normal and malignant hematopoiesis | journal = Current Opinion in Hematology | volume = 15 | issue = 4 | pages = 352–8 | date = Jul 2008 | pmid = 18536574 | doi = 10.1097/MOH.0b013e328303e15d }} 7. ^{{cite journal | vauthors = Lulla RR, Costa FF, Bischof JM, Chou PM, Bonaldo MF, Vanin EF, Soares MB | title = Identification of Differentially Expressed MicroRNAs in Osteosarcoma | journal = Sarcoma | volume = 2011 | pages = 732690 | year = 2011 | pmid = 21789031 | pmc = 3140035 | doi = 10.1155/2011/732690 }} 8. ^{{cite journal | vauthors = Vasilescu C, Rossi S, Shimizu M, Tudor S, Veronese A, Ferracin M, Nicoloso MS, Barbarotto E, Popa M, Stanciulea O, Fernandez MH, Tulbure D, Bueso-Ramos CE, Negrini M, Calin GA | title = MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis | journal = PLOS ONE | volume = 4 | issue = 10 | pages = e7405 | date = 2009-10-12 | pmid = 19823581 | pmc = 2756627 | doi = 10.1371/journal.pone.0007405 | editor1-last = Gold | editor1-first = Jeffrey A }} 9. ^{{cite journal | vauthors = Magrelli A, Azzalin G, Salvatore M, Viganotti M, Tosto F, Colombo T, Devito R, Di Masi A, Antoccia A, Lorenzetti S, Maranghi F, Mantovani A, Tanzarella C, Macino G, Taruscio D | title = Altered microRNA Expression Patterns in Hepatoblastoma Patients | journal = Translational Oncology | volume = 2 | issue = 3 | pages = 157–63 | date = Aug 2009 | pmid = 19701500 | pmc = 2730135 | doi=10.1593/tlo.09124}} Further reading{{refbegin}}
1 : MicroRNA |
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