| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.[1] Function microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.[1] References 1. ^1 {{cite web | title = Entrez Gene: MicroRNA 194-1 | url = https://www.ncbi.nlm.nih.gov/gene/406969| accessdate = 2014-05-29 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Sundaram P, Hultine S, Smith LM, Dews M, Fox JL, Biyashev D, Schelter JM, Huang Q, Cleary MA, Volpert OV, Thomas-Tikhonenko A | title = p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers | journal = Cancer Research | volume = 71 | issue = 24 | pages = 7490–501 | date = Dec 2011 | pmid = 22028325 | pmc = 3242824 | doi = 10.1158/0008-5472.CAN-11-1124 }}
- {{cite journal | vauthors = Dong P, Kaneuchi M, Watari H, Hamada J, Sudo S, Ju J, Sakuragi N | title = MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1 | journal = Molecular Cancer | volume = 10 | pages = 99 | year = 2011 | pmid = 21851624 | pmc = 3173388 | doi = 10.1186/1476-4598-10-99 }}
- {{cite journal | vauthors = Song Y, Zhao F, Wang Z, Liu Z, Chiang Y, Xu Y, Gao P, Xu H | title = Inverse association between miR-194 expression and tumor invasion in gastric cancer | journal = Annals of Surgical Oncology | volume = 19 Suppl 3 | pages = S509–17 | date = Jul 2012 | pmid = 21845495 | doi = 10.1245/s10434-011-1999-2 }}
- {{cite journal | vauthors = Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T | title = New microRNAs from mouse and human | journal = RNA | volume = 9 | issue = 2 | pages = 175–9 | date = Feb 2003 | pmid = 12554859 | pmc = 1370382 | doi = 10.1261/rna.2146903 }}
- {{cite journal | vauthors = Xu J, Kang Y, Liao WM, Yu L | title = MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5 | journal = PLOS ONE | volume = 7 | issue = 3 | pages = e31861 | year = 2012 | pmid = 22396742 | pmc = 3291608 | doi = 10.1371/journal.pone.0031861 }}
- {{cite journal | vauthors = Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM | title = Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development | journal = Cancer Cell | volume = 18 | issue = 4 | pages = 367–81 | date = Oct 2010 | pmid = 20951946 | pmc = 3561766 | doi = 10.1016/j.ccr.2010.09.005 }}
- {{cite journal | vauthors = Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ | title = Reduced accumulation of specific microRNAs in colorectal neoplasia | journal = Molecular Cancer Research | volume = 1 | issue = 12 | pages = 882–91 | date = Oct 2003 | pmid = 14573789 }}
{{refend}}{{NLM content}}{{gene-1-stub}} 2 : Genes|Non-coding RNA |