| 释义 |
- Function
- References
- Further reading
{{Underlinked|date=January 2015}}{{Infobox_gene}}MicroRNA 34a is a MicroRNA that in humans is encoded by the MIR34A gene.[1] Function microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. References 1. ^{{cite web | title = Entrez Gene: MicroRNA 34a | url = https://www.ncbi.nlm.nih.gov/gene/407040 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Pang RT, Leung CO, Ye TM, Liu W, Chiu PC, Lam KK, Lee KF, Yeung WS | title = MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells | journal = Carcinogenesis | volume = 31 | issue = 6 | pages = 1037–44 | date = June 2010 | pmid = 20351093 | doi = 10.1093/carcin/bgq066 }}
- {{cite journal | vauthors = Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP | title = Vertebrate microRNA genes | journal = Science | volume = 299 | issue = 5612 | pages = 1540 | date = March 2003 | pmid = 12624257 | pmc = | doi = 10.1126/science.1080372 }}
- {{cite journal | vauthors = Zauli G, Voltan R, di Iasio MG, Bosco R, Melloni E, Sana ME, Secchiero P | title = miR-34a induces the downregulation of both E2F1 and B-Myb oncogenes in leukemic cells | journal = Clinical Cancer Research | volume = 17 | issue = 9 | pages = 2712–24 | date = May 2011 | pmid = 21367750 | doi = 10.1158/1078-0432.CCR-10-3244 }}
- {{cite journal | vauthors = Forte E, Salinas RE, Chang C, Zhou T, Linnstaedt SD, Gottwein E, Jacobs C, Jima D, Li QJ, Dave SS, Luftig MA | title = The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells | journal = Journal of Virology | volume = 86 | issue = 12 | pages = 6889–98 | date = June 2012 | pmid = 22496226 | pmc = 3393554 | doi = 10.1128/JVI.07056-11 }}
- {{cite journal | vauthors = Navarro F, Gutman D, Meire E, Cáceres M, Rigoutsos I, Bentwich Z, Lieberman J | title = miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53 | journal = Blood | volume = 114 | issue = 10 | pages = 2181–92 | date = September 2009 | pmid = 19584398 | doi = 10.1182/blood-2009-02-205062 }}
- {{cite journal | vauthors = Welch C, Chen Y, Stallings RL | title = MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells | journal = Oncogene | volume = 26 | issue = 34 | pages = 5017–22 | date = July 2007 | pmid = 17297439 | doi = 10.1038/sj.onc.1210293 }}
- {{cite journal | vauthors = Siemens H, Jackstadt R, Hünten S, Kaller M, Menssen A, Götz U, Hermeking H | title = miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions | journal = Cell Cycle | volume = 10 | issue = 24 | pages = 4256–71 | date = December 2011 | pmid = 22134354 | doi = 10.4161/cc.10.24.18552 }}
- {{cite journal | vauthors = Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Deng G, Dahiya R | title = MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells | journal = PLoS One | volume = 7 | issue = 1 | pages = e29722 | year = 2012 | pmid = 22235332 | pmc = 3250472 | doi = 10.1371/journal.pone.0029722 }}
- {{cite journal | vauthors = Lou WJ, Chen Q, Liu L, Qian C | title = [miR-34s--a tumor suppression protein p53 highly related microRNA] | journal = Yi Chuan = Hereditas / Zhongguo Yi Chuan Xue Hui Bian Ji | volume = 32 | issue = 5 | pages = 423–30 | date = May 2010 | pmid = 20466628 | doi = 10.3724/SP.J.1005.2010.00423 }}
{{refend}}{{NLM content}}{{gene-1-stub}} |