| 词条 | Mir-48 |
| 释义 |
Gene structure and locationAlong with mir-241, mir-48 is found in the lin-58 allele between the genes hum-5 and unc-76.[2] It is related to (at least) three other miRNAs (let-7,mir-84 and mir-241), with which it shares eight identical bases at the 5' end of the mature miRNA.[3] Functionmir-48, along with let-7, mir-84 and mir-241, controls developmental timing events in C. elegans proliferative seam cells and hypodermal syncytial cells. Double mutations in mir-48 and mir-214 result in worms displaying a retarded cell lineage phenotype; extra seam cells are observed in the L3 and L4 developmental stages when compared to wild-type worms. It is thought that the extra cells arise due to mutant miRNAs being unable to repress the gene hbl-1, which also plays a role in developmental timing.[3] References1. ^{{Cite journal | last1 = Li | first1 = M. | last2 = Jones-Rhoades | first2 = M. W. | last3 = Lau | first3 = N. C. | last4 = Bartel | first4 = D. P. | last5 = Rougvie | first5 = A. E. | doi = 10.1016/j.devcel.2005.08.002 | title = Regulatory Mutations of mir-48, a C. Elegans let-7 Family MicroRNA, Cause Developmental Timing Defects | journal = Developmental Cell | volume = 9 | issue = 3 | pages = 415–422 | year = 2005 | pmid = 16139229}} {{miRNA precursor families}}{{DEFAULTSORT:Mir-48}}{{genetics-stub}}2. ^{{Cite journal | last1 = Lau | first1 = N. C. | last2 = Lim | first2 = L. P. | last3 = Weinstein | first3 = E. G. | last4 = Bartel | first4 = D. P. | title = An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans | journal = Science | volume = 294 | issue = 5543 | pages = 858–862 | year = 2001 | pmid = 11679671 | doi = 10.1126/science.1065062}} 3. ^1 {{Cite journal | last1 = Abbott | first1 = A. L. | last2 = Alvarez-Saavedra | first2 = E. | last3 = Miska | first3 = E. A. | last4 = Lau | first4 = N. C. | last5 = Bartel | first5 = D. P. | last6 = Horvitz | first6 = H. R. | last7 = Ambros | first7 = V. | doi = 10.1016/j.devcel.2005.07.009 | title = The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans | journal = Developmental Cell | volume = 9 | issue = 3 | pages = 403–414 | year = 2005 | pmid = 16139228}} 3 : MicroRNA|Non-coding RNA|Caenorhabditis elegans genes |
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