| 释义 |
- mir-625 and gastric cancer
- See also
- References
- Further reading
- External links
{{Orphan|date=October 2013}}{{Infobox rfam
| Name = mir-625
| image =
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| caption =
| Symbol = mir-625
| AltSymbols =
| Rfam = RF01017
| miRBase =
| miRBase_family = MIPF0000534
| RNA_type = microRNA
| Tax_domain = Eukaryota;
| GO =
| SO =
| CAS_number =
| EntrezGene =
| HGNCid =
| OMIM =
| PDB =
| RefSeq =
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| LocusSupplementaryData =
}}In molecular biology mir-625 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. Many microRNAs play important roles in cancer development and progression. mir-625 and gastric cancermir-625 has been shown to be down regulated in gastric cancers. This is important, as mir-625 is responsible for the regulation of metastasis in gastric tumour cells, and therefore downregulation of mir-625 results in increased metastasis.[1] mir-625 is thought to act by inhibiting the ILK protein.[1] See also References 1. ^1 {{cite journal | vauthors = Wang M, Li C, Nie H, Lv X, Qu Y, Yu B, Su L, Li J, Chen X, Ju J, Yu Y, Yan M, Gu Q, Zhu Z, Liu B | title = Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK | journal = FEBS Letters | volume = 586 | issue = 16 | pages = 2382–8 | date = July 2012 | pmid = 22677169 | doi = 10.1016/j.febslet.2012.05.050 }}
Further reading {{refbegin}}- {{cite journal | vauthors = Roth C, Stückrath I, Pantel K, Izbicki JR, Tachezy M, Schwarzenbach H | title = Low levels of cell-free circulating miR-361-3p and miR-625 as blood-based markers for discriminating malignant from benign lung tumors | journal = PLOS One | volume = 7 | issue = 6 | pages = e38248 | year = 2012 | pmid = 22675530 | pmc = 3366929 | doi = 10.1371/journal.pone.0038248 | editor1-last = Lau | editor1-first = Kin Mang }}
- {{cite journal | vauthors = Bae J, Won M, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH, Suh DS | title = Identification of differentially expressed microRNAs in endometrial cancer cells after progesterone treatment | journal = International Journal of Gynecological Cancer | volume = 22 | issue = 4 | pages = 561–5 | date = May 2012 | pmid = 22543862 | pmc = | doi = 10.1097/IGC.0b013e31824927db }}
- {{cite journal | vauthors = Huang JJ, Yu J, Li JY, Liu YT, Zhong RQ | title = Circulating microRNA expression is associated with genetic subtype and survival of multiple myeloma | journal = Medical Oncology | volume = 29 | issue = 4 | pages = 2402–8 | date = December 2012 | pmid = 22447484 | pmc = | doi = 10.1007/s12032-012-0210-3 }}
- {{cite journal | vauthors = Yu J, Li A, Hong SM, Hruban RH, Goggins M | title = MicroRNA alterations of pancreatic intraepithelial neoplasias | journal = Clinical Cancer Research | volume = 18 | issue = 4 | pages = 981–92 | date = February 2012 | pmid = 22114139 | pmc = 3288338 | doi = 10.1158/1078-0432.CCR-11-2347 }}
- {{cite journal | vauthors = Xu YW, Wang B, Ding CH, Li T, Gu F, Zhou C | title = Differentially expressed micoRNAs in human oocytes | journal = Journal of Assisted Reproduction and Genetics | volume = 28 | issue = 6 | pages = 559–66 | date = June 2011 | pmid = 21647640 | pmc = 3158253 | doi = 10.1007/s10815-011-9590-0 }}
- {{cite journal | vauthors = Xu L, Liang YN, Luo XQ, Liu XD, Guo HX | title = [Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia] | journal = Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi | volume = 32 | issue = 3 | pages = 178–81 | date = March 2011 | pmid = 21535956 }}
{{refend}} External links - {{Rfam|id=RF01017|name=mir-625 microRNA precursor family}}
{{genetics-stub}} 2 : MicroRNA|MicroRNA precursor families |