| 词条 | Mir-632 microRNA precursor family |
| 释义 |
| Name = mir-632 | image = | width = | caption = | Symbol = mir-632 | AltSymbols = | Rfam = RF01010 | miRBase = | miRBase_family = MIPF0000527 | RNA_type = microRNA | Tax_domain = Eukaryota; | GO = | SO = | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} In molecular biology mir-632 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-632 and MDSmiR-632 has been identified as one of three key miRNAs associated with the anti-ageing myelodysplastic syndromes (MDS). In particular, its levels show high discrimination between MDS and normal controls, and expression is decreased in MDS.[1] In this way it can be used as a potential diagnostic marker for MDS. DNAJB6 proteinmiR-632 targets the coding region of the DNAJB6 protein, a member of the Heat Shock Protein 40 (HSP40) family which shows constitutive expression. DNAJB6 is known to be a negative regulator of tumour progression in breast cancer and its levels are compromised in advanced tumour progression. miR-632 has been linked to be downregulation of DNAJB6 and is capable of silencing both spliced variants of this protein.[2] It is currently unknown whether miR-632 may be just one of many negative regulators controlling DNAJB6 levels. See also
References1. ^{{cite journal |vauthors=Erdogan B, Facey C, Qualtieri J, Tedesco J, Rinker E, Isett RB, etal | title=Diagnostic microRNAs in myelodysplastic syndrome. | journal=Exp Hematol | year= 2011 | volume= 39 | issue= 9 | pages= 915–926.e2 | pmid=21703983 | doi=10.1016/j.exphem.2011.06.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21703983 }} 2. ^{{cite journal|vauthors=Mitra A, Rostas JW, Dyess DL, Shevde LA, Samant RS | title=Micro-RNA-632 downregulates DNAJB6 in breast cancer. | journal=Lab Invest | year= 2012 | volume= 92| issue= 9| pages= 1310–7| pmid=22710984 | doi=10.1038/labinvest.2012.87 | pmc= 3660857| url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22710984 }} External links
2 : MicroRNA|MicroRNA precursor families |
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