| 释义 |
- Gastric cancer suppression
- miR-155 upregulation and other molecular targets
- See also
- References
- Further reading
- External links
{{Infobox rfam
| Name = mir-663
| image =
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| caption =
| Symbol = mir-663
| AltSymbols =
| Rfam = RF00957
| miRBase =
| miRBase_family = MIPF0000462
| RNA_type = microRNA
| Tax_domain = Eukaryota;
| GO =
| SO =
| CAS_number =
| EntrezGene =
| HGNCid =
| OMIM =
| PDB =
| RefSeq =
| Chromosome =
| Arm =
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| LocusSupplementaryData =
}}In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. Gastric cancer suppressionmiR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer (GC) cell lines. miR-663 introduction into the two human GC cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation.[1] Transfection with miR-663 also sees a resultant upregulation of cyclin B. miR-155 upregulation and other molecular targetsResveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells.[2] Endogenous activator protein-1 (AP-1) activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipolysaccharide upregulation of miR-155 by resveratrol.[3] miR-663 also directly targets EEF1A2, transaltion elongation factor and well-known protooncogene.[2][4] See also References 1. ^{{cite journal | vauthors = Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, Sun L, Liu J, Yang Z, Ran Y | title = Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells | journal = Oncology Reports | volume = 24 | issue = 1 | pages = 105–12 | date = July 2010 | pmid = 20514450 | pmc = | doi = 10.3892/or_00000834 }}
2. ^1 {{cite journal | vauthors = Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I | title = Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744 | journal = British Journal of Cancer | volume = 108 | issue = 11 | pages = 2304–11 | date = June 2013 | pmid = 23695020 | pmc = 3681015 | doi = 10.1038/bjc.2013.243 }}
3. ^{{cite journal | vauthors = Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM | title = Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD | journal = Carcinogenesis | volume = 31 | issue = 9 | pages = 1561–6 | date = September 2010 | pmid = 20622002 | pmc = | doi = 10.1093/carcin/bgq143 | url = https://hal.archives-ouvertes.fr/hal-00514095/document }}
4. ^{{cite journal | vauthors = Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM | title = Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer | journal = Nature Genetics | volume = 31 | issue = 3 | pages = 301–5 | date = July 2002 | pmid = 12053177 | doi = 10.1038/ng904 }}
Further reading {{refbegin|32em}}- {{cite journal | vauthors = Liang P, Lv C, Jiang B, Long X, Zhang P, Zhang M, Xie T, Huang X | title = MicroRNA profiling in denatured dermis of deep burn patients | journal = Burns | volume = 38 | issue = 4 | pages = 534–40 | date = June 2012 | pmid = 22360957 | pmc = | doi = 10.1016/j.burns.2011.10.014 }}
- {{cite journal | vauthors = Lu J, Kwan BC, Lai FM, Tam LS, Li EK, Chow KM, Wang G, Li PK, Szeto CC | title = Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis | journal = Nephrology | volume = 17 | issue = 4 | pages = 346–51 | date = May 2012 | pmid = 22295894 | pmc = | doi = 10.1111/j.1440-1797.2012.01573.x }}
- {{cite journal | vauthors = Yi C, Wang Q, Wang L, Huang Y, Li L, Liu L, Zhou X, Xie G, Kang T, Wang H, Zeng M, Ma J, Zeng Y, Yun JP | title = MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma | journal = Oncogene | volume = 31 | issue = 41 | pages = 4421–33 | date = October 2012 | pmid = 22249270 | pmc = | doi = 10.1038/onc.2011.629 }}
- {{cite journal | vauthors = Yang Y, Wang LL, Li YH, Gao XN, Liu Y, Yu L | title = Effect of CpG island methylation on microRNA expression in the k-562 cell line | journal = Biochemical Genetics | volume = 50 | issue = 1-2 | pages = 122–34 | date = February 2012 | pmid = 22089542 | pmc = | doi = 10.1007/s10528-011-9478-9 }}
- {{cite journal | vauthors = Marques FZ, Campain AE, Tomaszewski M, Zukowska-Szczechowska E, Yang YH, Charchar FJ, Morris BJ | title = Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs | journal = Hypertension | volume = 58 | issue = 6 | pages = 1093–8 | date = December 2011 | pmid = 22042811 | pmc = | doi = 10.1161/HYPERTENSIONAHA.111.180729 }}
- {{cite journal | vauthors = Borgan E, Navon R, Vollan HK, Schlichting E, Sauer T, Yakhini Z, Lingjærde OC, Sørlie T, Børresen-Dale AL | title = Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue | journal = Molecular Oncology | volume = 5 | issue = 6 | pages = 564–76 | date = December 2011 | pmid = 21917534 | pmc = | doi = 10.1016/j.molonc.2011.08.004 }}
- {{cite journal | vauthors = Tili E, Michaille JJ | title = Resveratrol, MicroRNAs, Inflammation, and Cancer | journal = Journal of Nucleic Acids | volume = 2011 | pages = 102431 | year = 2011 | pmid = 21845215 | pmc = 3154569 | doi = 10.4061/2011/102431 }}
- {{cite journal | vauthors = Yang Y, Wang LL, Li YH, Gao XN, Yu L | title = [Expression level of miRNA-663 in different leukemic cell lines and its biological function] | journal = Zhongguo Shi Yan Xue Ye Xue Za Zhi | volume = 19 | issue = 2 | pages = 279–83 | date = April 2011 | pmid = 21518471 }}
- {{cite journal | vauthors = Jian P, Li ZW, Fang TY, Jian W, Zhuan Z, Mei LX, Yan WS, Jian N | title = Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663 | journal = Journal of Hematology & Oncology | volume = 4 | pages = 20 | date = April 2011 | pmid = 21518431 | pmc = 3094392 | doi = 10.1186/1756-8722-4-20 }}
- {{cite journal | vauthors = Ni CW, Qiu H, Jo H | title = MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 300 | issue = 5 | pages = H1762-9 | date = May 2011 | pmid = 21378144 | pmc = 3094086 | doi = 10.1152/ajpheart.00829.2010 }}
- {{cite journal | vauthors = Potapova A, Albat C, Hasemeier B, Haeussler K, Lamprecht S, Suerbaum S, Kreipe H, Lehmann U | title = Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution | journal = BMC Biotechnology | volume = 11 | pages = 6 | date = January 2011 | pmid = 21235780 | pmc = 3032674 | doi = 10.1186/1472-6750-11-6 }}
- {{cite journal | vauthors = Liu ZY, Zhang GL, Wang MM, Xiong YN, Cui HQ | title = MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation | journal = Asian Pacific Journal of Cancer Prevention | volume = 12 | issue = 11 | pages = 2819–23 | year = 2011 | pmid = 22393947 }}
- {{cite journal | vauthors = Dreher A, Rossing M, Kaczkowski B, Nielsen FC, Norrild B | title = Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR | journal = Biochemical and Biophysical Research Communications | volume = 403 | issue = 3-4 | pages = 357–62 | date = December 2010 | pmid = 21078297 | pmc = | doi = 10.1016/j.bbrc.2010.11.035 }}
- {{cite journal | vauthors = Tili E, Michaille JJ, Alder H, Volinia S, Delmas D, Latruffe N, Croce CM | title = Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells | journal = Biochemical Pharmacology | volume = 80 | issue = 12 | pages = 2057–65 | date = December 2010 | pmid = 20637737 | pmc = 3918904| doi = 10.1016/j.bcp.2010.07.003 }}
- {{cite journal | vauthors = Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM | title = Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD | journal = Carcinogenesis | volume = 31 | issue = 9 | pages = 1561–6 | date = September 2010 | pmid = 20622002 | pmc = | doi = 10.1093/carcin/bgq143 | url = https://hal.archives-ouvertes.fr/hal-00514095/document }}
- {{cite journal | vauthors = Marasa BS, Srikantan S, Martindale JL, Kim MM, Lee EK, Gorospe M, Abdelmohsen K | title = MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence | journal = Aging | volume = 2 | issue = 6 | pages = 333–43 | date = June 2010 | pmid = 20606251 | pmc = 2919253 | doi = 10.18632/aging.100159 }}
- {{cite journal | vauthors = Te JL, Dozmorov IM, Guthridge JM, Nguyen KL, Cavett JW, Kelly JA, Bruner GR, Harley JB, Ojwang JO | title = Identification of unique microRNA signature associated with lupus nephritis | journal = PLOS One | volume = 5 | issue = 5 | pages = e10344 | date = May 2010 | pmid = 20485490 | pmc = 2867940 | doi = 10.1371/journal.pone.0010344 | editor1-last = Means | editor1-first = Terry }}
- {{cite journal | vauthors = Buratti E, De Conti L, Stuani C, Romano M, Baralle M, Baralle F | title = Nuclear factor TDP-43 can affect selected microRNA levels | journal = The FEBS Journal | volume = 277 | issue = 10 | pages = 2268–81 | date = May 2010 | pmid = 20423455 | pmc = | doi = 10.1111/j.1742-4658.2010.07643.x }}
- {{cite journal | vauthors = Maes OC, Sarojini H, Wang E | title = Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts | journal = Journal of Cellular Physiology | volume = 221 | issue = 1 | pages = 109–19 | date = October 2009 | pmid = 19475566 | pmc = | doi = 10.1002/jcp.21834 }}
- {{cite journal | vauthors = Pizzimenti S, Ferracin M, Sabbioni S, Toaldo C, Pettazzoni P, Dianzani MU, Negrini M, Barrera G | title = MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation | journal = Free Radical Biology & Medicine | volume = 46 | issue = 2 | pages = 282–8 | date = January 2009 | pmid = 19022373 | pmc = | doi = 10.1016/j.freeradbiomed.2008.10.035 }}
- {{cite journal | vauthors = Lehmann U, Hasemeier B, Römermann D, Müller M, Länger F, Kreipe H | title = [Epigenetic inactivation of microRNA genes in mammary carcinoma] | journal = Verhandlungen Der Deutschen Gesellschaft Fur Pathologie | volume = 91 | pages = 214–20 | year = 2007 | pmid = 18314617 }}
- {{cite journal | vauthors = Lehmann U, Hasemeier B, Christgen M, Müller M, Römermann D, Länger F, Kreipe H | title = Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer | journal = The Journal of Pathology | volume = 214 | issue = 1 | pages = 17–24 | date = January 2008 | pmid = 17948228 | pmc = | doi = 10.1002/path.2251 }}
{{refend}} External links - {{Rfam|id=RF00957|name=mir-663 microRNA precursor family}}
2 : MicroRNA|MicroRNA precursor families |