| 释义 |
- References
- Further reading
{{Infobox_gene}}Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene.[1] It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.[2] It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.[3]References1. ^{{cite web | title = Entrez Gene: MTOR associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64223| accessdate = }}
2. ^{{cite web | title = UniProtKB – Q9BVC4 (LST8_HUMAN) | url = https://www.uniprot.org/uniprot/Q9BVC4 | accessdate = }}
3. ^{{cite journal | vauthors = Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C | title = mLST8 Promotes mTOR-Mediated Tumor Progression | journal = PLOS ONE | volume = 10 | issue = 4 | pages = e0119015 | date = 23 Apr 2015 | doi = 10.1371/journal.pone.0119015 | pmid = 25906254 | pmc = 4408021 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Ali SM, Sabatini DM |title=Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 19445–8 |year= 2005 |pmid= 15809305 |doi= 10.1074/jbc.C500125200 }}
- {{cite journal |vauthors=Rodgers BD, Levine MA, Bernier M, Montrose-Rafizadeh C |title=Insulin regulation of a novel WD-40 repeat protein in adipocytes. |journal=J. Endocrinol. |volume=168 |issue= 2 |pages= 325–32 |year= 2001 |pmid= 11182770 |doi= 10.1677/joe.0.1680325}}
- {{cite journal |vauthors=Long X, Lin Y, Ortiz-Vega S, etal |title=Rheb binds and regulates the mTOR kinase. |journal=Curr. Biol. |volume=15 |issue= 8 |pages= 702–13 |year= 2005 |pmid= 15854902 |doi= 10.1016/j.cub.2005.02.053 }}
- {{cite journal |vauthors=Kaizuka T, Hara T, Oshiro N, etal |title=Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. |journal=J. Biol. Chem. |volume=285 |issue= 26 |pages= 20109–16 |year= 2010 |pmid= 20427287 |doi= 10.1074/jbc.M110.121699 |pmc=2888423}}
- {{cite journal |vauthors=Loewith R, Jacinto E, Wullschleger S, etal |title=Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. |journal=Mol. Cell |volume=10 |issue= 3 |pages= 457–68 |year= 2002 |pmid= 12408816 |doi= 10.1016/S1097-2765(02)00636-6}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129}}
- {{cite journal |vauthors=Sarbassov DD, Sabatini DM |title=Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39505–9 |year= 2005 |pmid= 16183647 |doi= 10.1074/jbc.M506096200 }}
- {{cite journal |vauthors=Oshiro N, Yoshino K, Hidayat S, etal |title=Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. |journal=Genes Cells |volume=9 |issue= 4 |pages= 359–66 |year= 2004 |pmid= 15066126 |doi= 10.1111/j.1356-9597.2004.00727.x }}
- {{cite journal |vauthors=Inoki K, Ouyang H, Li Y, Guan KL |title=Signaling by target of rapamycin proteins in cell growth control. |journal=Microbiol. Mol. Biol. Rev. |volume=69 |issue= 1 |pages= 79–100 |year= 2005 |pmid= 15755954 |doi= 10.1128/MMBR.69.1.79-100.2005 |pmc=1082789}}
- {{cite journal |vauthors=Behrends C, Sowa ME, Gygi SP, Harper JW |title=Network organization of the human autophagy system. |journal=Nature |volume=466 |issue= 7302 |pages= 68–76 |year= 2010 |pmid= 20562859 |doi= 10.1038/nature09204 |pmc=2901998}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Kawai S, Enzan H, Hayashi Y, etal |title=Vinculin: a novel marker for quiescent and activated hepatic stellate cells in human and rat livers. |journal=Virchows Arch. |volume=443 |issue= 1 |pages= 78–86 |year= 2003 |pmid= 12719976 |doi= 10.1007/s00428-003-0804-4 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}
- {{cite journal |vauthors=Kim DH, Sarbassov DD, Ali SM, etal |title=GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 895–904 |year= 2003 |pmid= 12718876 |doi= 10.1016/S1097-2765(03)00114-X}}
- {{cite journal |vauthors=Jacinto E, Loewith R, Schmidt A, etal |title=Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. |journal=Nat. Cell Biol. |volume=6 |issue= 11 |pages= 1122–8 |year= 2004 |pmid= 15467718 |doi= 10.1038/ncb1183 }}
- {{cite journal |vauthors=Sarbassov DD, Guertin DA, Ali SM, Sabatini DM |title=Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. |journal=Science |volume=307 |issue= 5712 |pages= 1098–101 |year= 2005 |pmid= 15718470 |doi= 10.1126/science.1106148 }}
{{refend}}{{gene-16-stub}} |