| 释义 |
- References
- Further reading
{{Infobox_gene}}Methyl methanesulfonate-sensitivity protein 22-like also known as MMS22-like, DNA repair protein is a protein that in humans is encoded by the MMS22L gene.[1]==Model organisms== Mms22l knockout mouse phenotype| Characteristic | Phenotype |
|---|
| Homozygote viability | Abnormal | | Recessive lethal study | Abnormal | | Fertility | Normal | | Body weight | Normal | | Anxiety | Normal | | Neurological assessment | Normal | | Grip strength | Normal | | Hot plate | Normal | | Dysmorphology | Normal | | Indirect calorimetry | Normal | | Glucose tolerance test | Normal | | Auditory brainstem response | Normal | | DEXA | Normal | | Radiography | Normal | | Body temperature | Normal | | Eye morphology | Normal | | Clinical chemistry | Normal | | Haematology | Normal | | Peripheral blood lymphocytes | Normal | | Micronucleus test | Normal | | Heart weight | Normal | | Skin Histopathology | Normal | | Brain histopathology | Normal | | Eye Histopathology | Normal | | Salmonella infection | Normal[2] | | Citrobacter infection | Normal[3] | | All tests and analysis from[4][5] | Model organisms have been used in the study of MMS22L function. A conditional knockout mouse line, called Mms22ltm1a(EUCOMM)Wtsi[6] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[7][8][9]Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][10] Twenty six tests were carried out on mutant mice and two significant abnormalities were observed.[4] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals. [4] References 1. ^{{cite web | title = Entrez Gene: MMS22-like, DNA repair protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=253714}}
2. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAKN/salmonella-challenge/ |title=Salmonella infection data for Mms22l |publisher=Wellcome Trust Sanger Institute}}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAKN/citrobacter-challenge/ |title=Citrobacter infection data for Mms22l |publisher=Wellcome Trust Sanger Institute}}
4. ^1 2 3 {{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages = 925–7 }}
5. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
6. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Mms22l |title=International Knockout Mouse Consortium}}
7. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
8. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
9. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
10. ^{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}
Further reading - {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
- {{cite journal | vauthors = Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J | title = Identification of the MMS22L-TONSL complex that promotes homologous recombination | journal = Molecular Cell | volume = 40 | issue = 4 | pages = 632–44 | date = Nov 2010 | pmid = 21055984 | doi = 10.1016/j.molcel.2010.10.023 }}
- {{cite journal | vauthors = O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW | title = A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability | journal = Molecular Cell | volume = 40 | issue = 4 | pages = 645–57 | date = Nov 2010 | pmid = 21055985 | pmc = 3006237 | doi = 10.1016/j.molcel.2010.10.022 }}
- {{cite journal | vauthors = O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D | title = The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination | journal = Molecular Cell | volume = 40 | issue = 4 | pages = 619–31 | date = Nov 2010 | pmid = 21055983 | pmc = 3031522 | doi = 10.1016/j.molcel.2010.10.024 }}
- {{cite journal | vauthors = Piwko W, Olma MH, Held M, Bianco JN, Pedrioli PG, Hofmann K, Pasero P, Gerlich DW, Peter M | title = RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells | journal = The EMBO Journal | volume = 29 | issue = 24 | pages = 4210–22 | date = Dec 2010 | pmid = 21113133 | pmc = 3018799 | doi = 10.1038/emboj.2010.304 }}
- {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
{{refend}}{{gene-6-stub}} 1 : Genes mutated in mice |