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词条 Molybdopterin synthase sulfurtransferase
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = Molybdopterin synthase sulfurtransferase
| EC_number = 2.8.1.11
| CAS_number =
| IUBMB_EC_number = 2/8/1/11
| GO_code =
| image =
| width =
| caption =
}}Molybdopterin synthase sulfurtransferase ({{EC number|2.8.1.11}}, adenylyltransferase and sulfurtransferase MOCS3, Cnx5 (gene), molybdopterin synthase sulfurylase) is an enzyme with systematic name persulfurated L-cysteine desulfurase:(molybdopterin-synthase sulfur-carrier protein)-Gly-Gly sulfurtransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase

The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of molybdopterin synthase.

References

1. ^{{cite journal | vauthors = Matthies A, Nimtz M, Leimkühler S | title = Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry | journal = Biochemistry | volume = 44 | issue = 21 | pages = 7912–20 | date = May 2005 | pmid = 15910006 | doi = 10.1021/bi0503448 }}
2. ^{{cite journal | vauthors = Leimkühler S, Rajagopalan KV | title = A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli | journal = The Journal of Biological Chemistry | volume = 276 | issue = 25 | pages = 22024–31 | date = June 2001 | pmid = 11290749 | doi = 10.1074/jbc.M102072200 }}
3. ^{{cite journal | vauthors = Hänzelmann P, Dahl JU, Kuper J, Urban A, Müller-Theissen U, Leimkühler S, Schindelin H | title = Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains | journal = Protein Science | volume = 18 | issue = 12 | pages = 2480–91 | date = December 2009 | pmid = 19798741 | pmc = 2821267 | doi = 10.1002/pro.260 }}
4. ^{{cite journal | vauthors = Dahl JU, Urban A, Bolte A, Sriyabhaya P, Donahue JL, Nimtz M, Larson TJ, Leimkühler S | title = The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli | journal = The Journal of Biological Chemistry | volume = 286 | issue = 41 | pages = 35801–12 | date = October 2011 | pmid = 21856748 | pmc = 3195606 | doi = 10.1074/jbc.M111.282368 }}

External links

  • {{MeshName|Molybdopterin+synthase+sulfurtransferase}}
{{Sulfur-containing group transferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 2.8.1

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