| 词条 | Mono-BOC-cystamine |
| 释义 |
| ImageFile =BOC-cystamine.svg | ImageSize =200px | ImageAlt = | IUPACName =tert-Butyl (2-((2-aminoethyl)disulfanyl)ethyl)carbamate | OtherNames = |Section1={{Chembox Identifiers | CASNo = | PubChem = | ChemSpiderID = 11263014 | SMILES = NCCSSCCNC(=O)OC(C)(C)C | InChI = 1/C9H20N2O2S2/c1-9(2,3)13-8(12)11-5-7-15-14-6-4-10/h4-7,10H2,1-3H3,(H,11,12) | InChIKey = XGHNLHVZHBSTHO-UHFFFAOYAG | StdInChI = 1S/C9H20N2O2S2/c1-9(2,3)13-8(12)11-5-7-15-14-6-4-10/h4-7,10H2,1-3H3,(H,11,12) | StdInChIKey = XGHNLHVZHBSTHO-UHFFFAOYSA-N}} |Section2={{Chembox Properties | C=9 | H=20 | N=2 | O=2 | S=2 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Mono-BOC-cystamine (mono BOC protected cystamine ) is a tert-butyloxycarbonyl (BOC) derivative of cystamine used as crosslinker in biotechnology and molecular biology applications.[1] This compound was originally reported by Hansen et al.[2] UsesThe disulfide chain allows the mono-BOC-cystamine to be easily cleaved, allowing removal of the tagging residue when desired. Mono-BOC-cystamine is used as a crosslinker for the synthesis of cleavable photo-cross-linking reagent.[3] Mono-BOC-cystamine is used as a crosslinker for the synthesis of a biodegradable cystamine spacer in PGA-cystamine-Gd-DO3A, which shows improved MRI contrast for breast carcinoma imaging in mice. [4]Related compounds
References1. ^Mono BOC Cystamine{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}, Anachem 2. ^{{cite journal |author1=Hansen, J. B. |author2=Nielsen, M. C. |author3=Ehrbar, U. |author4=Buchardt, O. |title=Partially Protected Polyamines |journal=Synthesis |volume=1982 | issue=5|pages=404–405 |year=1982 | doi = 10.1055/s-1982-29814 |url=https://www.thieme-connect.de/ejournals/toc/synthesis/21714}} 3. ^{{cite journal |author=Peter E Nielsen, John B Hansen and Ole Buchard |title=Photochemical cross-linking of protein and DNA in chromatin |journal=Biochem J |pages=:519–526 |year=1984 }} 4. ^{{cite journal |author1=Tianyi Kea |author2=Yi Fengb |author3=Junyu Guoc |author4=Dennis L. Parkerc |author5=Zheng-Rong Lua |title=Biodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging |journal=Magnetic Resonance Imaging |volume=24 |issue=7 |pages=:931–940 |year=2006 |url=http://www.sciencedirect.com/science/article/pii/S0730725X06001342 |doi=10.1016/j.mri.2006.03.009|pmid=16916710 }} 5 : Organic disulfides|Carbamates|Amines|Reagents for biochemistry|Tert-butyl compounds |
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