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词条 MtlS RNA
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{{Orphan |date=November 2017}}MtlS RNA is a small non-coding RNA found in Vibrio cholerae and related bacteria.[1] MtlS is found in the mannitol operon, which encodes the mannitol-specific phosphotransferase system. The MtlS RNA is expressed when the bacteria are grown on carbon sources other than mannitol. MtlS is responsible for the post-transcriptional regulation of the MtlA protein. Overexpression of MtlS represses MtlA synthesis; it is proposed that this repression occurs as MtlS base pairs with the mtlA mRNA and occludes the ribosome binding site, thus inhibiting synthesis of the mannitol-specific phosphotransferase system.[2]

References

1. ^{{Cite journal |last=Liu |first=Jane M. |last2=Livny |first2=Jonathan |last3=Lawrence |first3=Michael S. |last4=Kimball |first4=Marc D. |last5=Waldor |first5=Matthew K. |last6=Camilli |first6=Andrew |date=April 2009 |title=Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing |journal=Nucleic Acids Research |volume=37 |issue=6 |pages=e46 |doi=10.1093/nar/gkp080 |pmc=2665243 |pmid=19223322}}
2. ^{{Cite journal | last1=Mustachio | first1=L. M. | last2=Aksit | first2=S. | last3=Mistry | first3=R. H. | last4=Scheffler | first4=R. | last5=Yamada | first5=A. | last6=Liu | first6=J. M. | doi=10.1128/JB.06153-11 | title=The Vibrio cholerae Mannitol Transporter is Regulated Posttranscriptionally by the MtlS Small Regulatory RNA | journal=Journal of Bacteriology | volume=194 | issue=3 | pages=598–606 | year=2011 | pmid=22101846 | pmc =3264093}}

External links

  • {{Rfam |id=RF02268 |name=MtlS RNA}}
{{molecular-cell-biology-stub}}

1 : Non-coding RNA
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