| 词条 | MY-5445 |
| 释义 |
| ImageFile = MY-5445.svg | ImageSize = 180 | IUPACName = N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = | PubChem = 1348 | ChemSpiderID = 1308 | SMILES = C1=CC=C(C=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC(=CC=C4)Cl | InChI = 1/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24) | InChIKey = CEHQLKSLMFIHBF-UHFFFAOYAQ | StdInChI = 1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-18-12-5-4-11-17(18)19(23-24-20)14-7-2-1-3-8-14/h1-13H,(H,22,24) | StdInChIKey = CEHQLKSLMFIHBF-UHFFFAOYSA-N | Section2 = {{Chembox Properties | C=20 | H=14 | Cl=1 | N=3 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}MY-5445 is a relatively specific phosphodiesterase 5 inhibitor.[1][2] See also
References1. ^{{cite journal | last1 = Nagendran | first1 = J | last2 = Archer | first2 = SL | last3 = Soliman | first3 = D | last4 = Gurtu | first4 = V | last5 = Moudgil | first5 = R | last6 = Haromy | first6 = A | last7 = St. Aubin | first7 = C | last8 = Webster | first8 = L | last9 = Rebeyka | first9 = IM | last10 = Ross | first10 = DB | last11 = Light | first11 = PE | last12 = Dyck | first12 = JR | last13 = Michelakis | first13 = ED | title = Phosphodiesterase Type 5 is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility | journal = Circulation | date = 17 July 2007 | volume = 116 | issue = 3 | pages = 238–48 | doi = 10.1161/circulationaha.106.655266 | pmid = 17606845 | url = http://circ.ahajournals.org/content/116/3/238.full.pdf}} {{Phosphodiesterase inhibitors}}{{organic-compound-stub}}2. ^{{cite journal | last1 = Hagiwara | first1 = M | last2 = Endo | first2 = T | last3 = Kanayama | first3 = T | last4 = Hidaka | first4 = H | title = Effect of 1-(3-Chloroanilino)-4-phenylphthalazine (MY-5445), a Specific Inhibitor of Cyclic GMP Phosphodiesterase, on Human Platelet Aggregation | journal = The Journal of Pharmacology and Experimental Therapeutics | date = February 1984 | volume = 228 | issue = 2 | pages = 467–71 | pmid = 6141286}} 2 : Phosphodiesterase inhibitors|Phthalazines |
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