| 词条 | Myticin |
| 释义 |
| Symbol = Myticin-prepro | Name = Myticin-prepro | image = | width = | caption = solution structure of the synthetic mytilin | Pfam = PF10690 | Pfam_clan = | InterPro = IPR019631 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = 58 | OPM protein = 2eem | CAZy = | CDD = }} Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis (Mediterranean mussel). Isoforms A and B show antibacterial activity against Gram-positive bacteria, while isoform C is additionally active against the fungus Fusarium oxysporum and bacterium Escherichia coli (streptomycin resistant strain D31).[1] Myticin-prepro is the precursor peptide. The mature molecule, named myticin, consists of 40 residues, with four intramolecular disulphide bridges and a cysteine array in the primary structure different from that of previously characterised cysteine-rich antimicrobial peptides. The first 20 amino acids are a putative signal peptide, and the antimicrobial peptide sequence is a 36-residue C-terminal extension. Such a structure suggests that myticins are synthesised as prepro-proteins that are then processed by various proteolytic events before storage in the haemocytes as the active peptide. Myticin precursors are expressed mainly in the haemocytes. References1. ^{{cite journal |vauthors=Mitta G, Hubert F, Nol T, Roch P | title = Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis | journal = Eur. J. Biochem. | volume = 265 | issue = 1 | pages = 71–8 |date=October 1999 | pmid = 10491159 | doi = 10.1046/j.1432-1327.1999.00654.x| url = }} {{InterPro content|IPR019631}} 2 : Antimicrobial peptides|Protein families |
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