词条 | N1-acetylpolyamine oxidase |
释义 |
| Name = N1-acetylpolyamine oxidase | EC_number = 1.5.3.13 | CAS_number = | IUBMB_EC_number = 1/5/3/13 | GO_code = | image = | width = | caption = }}N1-acetylpolyamine oxidase ({{EC number|1.5.3.13}}, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N1-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction (1) N1-acetylspermidine + O2 + H2O putrescine + 3-acetamidopropanal + H2O2 (2) N1-acetylspermine + O2 + H2O spermidine + 3-acetamidopropanal + H2O2 This enzyme also catalyses the reaction: N1,N12-diacetylspermine + O2 + H2O N1-acetylspermidine + 3-acetamamidopropanal + H2O2. References1. ^{{cite journal | vauthors = Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW | title = Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion | journal = The Biochemical Journal | volume = 370 | issue = Pt 1 | pages = 19–28 | date = February 2003 | pmid = 12477380 | pmc = 1223169 | doi = 10.1042/BJ20021779 }} 2. ^{{cite journal | vauthors = Järvinen A, Grigorenko N, Khomutov AR, Hyvönen MT, Uimari A, Vepsäläinen J, Sinervirta R, Keinänen TA, Vujcic S, Alhonen L, Porter CW, Jänne J | title = Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines | journal = The Journal of Biological Chemistry | volume = 280 | issue = 8 | pages = 6595–601 | date = February 2005 | pmid = 15611107 | doi = 10.1074/jbc.M412788200 }} 3. ^{{cite journal | vauthors = Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA | title = Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity | journal = Cancer Chemotherapy and Pharmacology | volume = 56 | issue = 1 | pages = 83–90 | date = July 2005 | pmid = 15791459 | doi = 10.1007/s00280-004-0936-5 }} 4. ^{{cite journal | vauthors = Wu T, Yankovskaya V, McIntire WS | title = Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase | journal = The Journal of Biological Chemistry | volume = 278 | issue = 23 | pages = 20514–25 | date = June 2003 | pmid = 12660232 | doi = 10.1074/jbc.M302149200 }} External links
1 : EC 1.5.3 |
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