| 词条 | N,alpha-Diethylphenylethylamine |
| 释义 |
| drug_name = N,α-Diethylphenylethylamine | IUPAC_name = N-Ethyl-1-phenylbutan-2-amine | image = N,α-Diethylphenylethylamine.svg | width = 200 | tradename = | legal_NZ = Class C | legal_CA = Schedule I | legal_UK = Class A | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | CAS_number = 119486-07-6 | CAS_supplemental = 29805-52-5 (HCl) | PubChem = 14833603 | ChemSpiderID = 27101303 | synonyms = N,α-DEPEA | C=12 | H=19 | N=1 | smiles = C(C)NC(CC1=CC=CC=C1)CC | StdInChI = 1S/C12H19N/c1-3-12(13-4-2)10-11-8-6-5-7-9-11/h5-9,12-13H,3-4,10H2,1-2H3 | StdInChIKey = KHWYSUBVXWWBRB-UHFFFAOYSA-N }} N,α-Diethylphenylethylamine (N,α-DEPEA, 2-ethylamino-1-phenylbutane, EAPB) is a close chemical analog of methamphetamine which has been sold as a designer drug.[1][2][3] It was originally patented by Knoll Pharma as one of several analogs for pharmaceutical applications. In animals models these analogs showed properties of cognitive enhancement and increased pain tolerance.[4] Nevertheless, this class of compounds was never developed into a medicine. {{nowrap|N,α-DEPEA}} has not been studied in humans, but experts such as Pieter Cohen of Harvard Medical School expect it to be less potent than methamphetamine, but greater than ephedrine.[5]Adulterant in nutritional supplementsIn January 2013, the Korean authorities reported seizing a large quantity of the pure material, predicting it would soon be found on the market.[6] Later in 2013, it was found as an adulterant in biologically significant amounts in the pre-workout supplements Craze (marketed by Driven Sports, Inc.) and Detonate (marketed by Gaspari Nutrition).[4][7] It was falsely claimed to be Dendrobium extract.[5][8][9] See also
References1. ^{{cite journal | url=http://www.sciencedirect.com/science/article/pii/S0731708515300790 | title=Determination of designer doping agent – 2-ethylamino-1-phenylbutane – in dietary supplements and excretion study following single oral supplement dose |author1=Marzena Wójtowicz |author2=Anna Jarek |author3=Katarzyna Chajewska |author4=Ewa Turek-Lepa |author5=Dorota Kwiatkowska | journal=Journal of Pharmaceutical and Biomedical Analysis | date=November 2015 | volume=115 | pages=523–533 | doi=10.1016/j.jpba.2015.07.025 | pmid=26311473}} {{Stimulants}}{{Nootropics}}{{Phenethylamines}}{{DEFAULTSORT:Diethylphenylethylamine, N,alpha-}}2. ^{{cite journal | url=http://jat.oxfordjournals.org/content/38/2/106 | title=Designer phenethylamines routinely found in human urine: 2-ethylamino-1-phenylbutane and 2-amino-1-phenylbutane. |author1=Victor Uralets |author2=Mike App |author3=Sumandeep Rana |author4=Stewart Morgan |author5=Wayne Ross | journal=Journal of Analytical Toxicology | date=January 2014 | volume=38 | issue=2 | pages=106–109 | doi=10.1093/jat/bkt121 | pmid=24451085}} 3. ^{{cite web | url=https://www.caymanchem.com/app/template/Product.vm/catalog/9001863 | title=2-Ethylamino-1-phenylbutane | publisher=Cayman Chemical | accessdate=4 November 2015}} 4. ^1 {{cite journal | doi = 10.1007/s11419-013-0205-6| title = Identification and quantitation of N,α-diethylphenethylamine in preworkout supplements sold via the Internet| journal = Forensic Toxicology| volume = 32| pages = 148–153| year = 2013| last1 = Lee| first1 = Jaesin| last2 = Venhuis| first2 = Bastiaan J.| last3 = Heo| first3 = Sewoong| last4 = Choi| first4 = Hyeyoung| last5 = Seol| first5 = Ilung| last6 = Kim| first6 = Eunmi}} 5. ^1 {{cite web | url = http://www.nutraingredients-usa.com/Regulation/Craze-manufacturer-disputes-NSF-s-discovery-of-drug-tainting | title = Craze manufacturer disputes NSF's discovery of drug tainting | publisher = Nutraingredients | date = October 17, 2013}} 6. ^{{cite journal | title = Identification of N-ethyl-α-ethylphenethylamine in crystalline powder seized for suspected drug trafficking: A research chemical or a new designer drug? | journal = Forensic Toxicology | volume = 31 | pages = 54–58 | date = January 2013| doi = 10.1007/s11419-012-0158-1 |last1 = Lee|first1 = Jaesin| last2 = Choe | first2 = Sanggil | last3 = Choi | first3 = Hyeyoung | last4 = Heo | first4 = Sewoong | last5 = Kim | first5 = Eunmi | last6 = Kim | first6 = Hyunju | last7 = Bang | first7 = Eunjung | last8 = Chung | first8 = Heesun }} 7. ^{{Cite news | url = https://www.usatoday.com/story/news/nation/2013/10/14/tests-of-supplements-craze-and-detonate-find-methamphetamine-like-compound/2968041/ | publisher = USA Today | date = October 25, 2013 | title = Popular sports supplements contain meth-like compound}} 8. ^{{cite journal | doi = 10.1002/dta.1578| pmid = 24124092| title = A methamphetamine analog (N,α-diethyl-phenylethylamine) identified in a mainstream dietary supplement| journal = Drug Testing and Analysis| volume = 6| issue = 7–8| pages = 805–7| year = 2014| last1 = Cohen| first1 = Pieter A.| last2 = Travis| first2 = John C.| last3 = Venhuis| first3 = Bastiaan J.}} 9. ^Warning issued over CRAZE sports supplement. New Zealand Herald, 13 November 2013 4 : Designer drugs|Norepinephrine-dopamine releasing agents|Phenethylamines|Substituted amphetamines |
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