Santísima Trinidad was the name of several Spanish ships:
{{ship|Spanish ship|Santísima Trinidad|1751}}, the largest of the Manilla galleons
{{ship|Spanish ship|Nuestra Señora de la Santísima Trinidad}}, a first-rate ship of the line officially named Santísima Trinidad in 1768; launched in 1769; captured at the Battle of Trafalgar, but later sank in a storm