| 词条 | Specificity factor |
| 释义 |
A specificity factor is an amino acid sequence that mediates target recognition in RNA polymerase.[1] An example is the sigma subunit of the Escherichia coli RNA polymerase holoenzyme which regulates a binding σ subunit of molecular weight 70 kDa. Under some conditions, some of the 70-kDa subunits are replaced by one of the other, more-specific factors. For instance, when bacteria are subjected to heat stress, some of the 70-kDa subunits are replaced by a 32-kDa subunit; when bound to σ32, RNA polymerase is directed to a specialized set of promoters with a different consensus sequence. References1. ^{{cite journal|url=http://www.jbc.org/content/266/33/22671.full.pdf|date=1991|title=The Yeast Mitochondrial RNA Polymerase Specificity Factor, MTF1, Is Similar to Bacterial 0 Factors|first1=Sei Heon |last1=Jang |first2=Judith A. |last2=Jaehnings|journal=The Journal of Biological Chemistry|volume=266|issue=39|pages=22671-22677}} {{molecular-biology-stub}} 2 : Transcription factors|DNA |
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