| 词条 | NMP-7 |
| 释义 |
| IUPAC_name = (9-pentylcarbazol-3-yl)-piperidin-1-ylmethanone | image = NMP-7_structure.png | width = 200 | pregnancy_category = | legal_status = | CAS_number = 1358039-07-2 | ATC_prefix = | ATC_suffix = | PubChem = 46871949 | ChemSpiderID = 27470961 | StdInChI = 1S/C23H28N2O/c1-2-3-7-16-25-21-11-6-5-10-19(21)20-17-18(12-13-22(20)25)23(26)24-14-8-4-9-15-24/h5-6,10-13,17H,2-4,7-9,14-16H2,1H3 | StdInChIKey = NZEVKZAEMSMLMC-UHFFFAOYSA-N | C=23|H=28|N=2|O=1 | molecular_weight = 348.480 g/mol | smiles = c3cccc1c3n(CCCCC)c(cc2)c1cc2C(=O)N4CCCCC4 }}NMP-7 is a drug which acts as both a non-selective agonist of the CB1 and CB2 cannabinoid receptors, and also as a blocker of T-type calcium channels, the target of anticonvulsant drugs such as ethosuximide. NMP-7 has an agonist EC50 of 96.9nM at CB1 and 10.5nM at CB2, and an IC50 of 1.84μM for blocking Cav3.2 T-type calcium channels. In animal studies it produces potent analgesic effects in a variety of different tests.[1] References1. ^You H, Gadotti VM, Petrov RR, Zamponi GW, Diaz P. Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands. Molecular Pain. 2011 Nov 17;7:89. {{PMID|22093952}} {{Cannabinoids}}{{cannabinoid-stub}} 2 : Cannabinoids|Carbazoles |
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