| 词条 | O-1871 |
| 释义 |
| IUPAC_name = 2-(3,3-dimethylcyclohexyl)-5-(2-methyloctan-2-yl)benzene-1,3-diol | image = O-1871_structure.png | width = 280 | tradename = | pregnancy_category = | legal_status = Banned as cyclohexylphenol derivative (US, UK) | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 620964-96-7 | ATC_prefix = none | ATC_suffix = | PubChem = 10405368 | ChemSpiderID = 8580806 | C=23 | H=38 | O=2 | molecular_weight = 346.55 g/mol | smiles = CC(C1)(C)CCCC1C2=C(O)C=C(C(C)(C)CCCCCC)C=C2O | StdInChI = 1S/C23H38O2/c1-6-7-8-9-13-23(4,5)18-14-19(24)21(20(25)15-18)17-11-10-12-22(2,3)16-17/h14-15,17,24-25H,6-13,16H2,1-5H3 | StdInChIKey = WBSPBIRKSHKQQD-UHFFFAOYSA-N }} O-1871 is a potent cannabinoid agonist which was invented by Billy R Martin and Raj K Razdan in 2002. It has a CB1 receptor affinity of 2.0nM and a CB2 receptor affinity of 0.3nM.[1] Structurally, O-1871 is a cyclohexylphenol derivative related to CP 47,497,[2] and so is illegal in some jurisdictions where CP 47,497 and its derivatives are banned. However the 3,3-dimethylcyclohexyl substituent of O-1871 can be replaced by various other groups, producing other potent compounds such as the cycloheptyl derivative O-1656 and the 2-adamantyl derivative O-1660, as well as the corresponding 3,5-dichlorophenyl derivative,[3] which are not cyclohexylphenol derivatives. See also
References1. ^{{cite patent |country= WO |number= 03091189 |status= application |title= Cannabinoids |pubdate= 6 November 2003 |gdate= |fdate= 20 June 2002 |pridate= 25 June 2002 |inventor= Martin BR, Razdan RK |assign1= University of Virginia }} {{Cannabinoids}}{{cannabinoid-stub}}2. ^{{cite journal | vauthors = Debruyne D, Le Boisselier R | title = Emerging drugs of abuse: current perspectives on synthetic cannabinoids | journal = Substance Abuse and Rehabilitation | volume = 6 | pages = 113–29 | pmid = 26543389 | doi = 10.2147/SAR.S73586 }} 3. ^{{cite patent |country= US |number= 2004087590 |status= application |title= Novel biphenyl and biphenyl-like cannabinoids|pubdate= 6 May 2004 |gdate= |fdate= |pridate= |inventor= Lai XZ, Lu D, Makriyannis A|assign1= University of Connecticut }} 1 : Cannabinoids |
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