| 词条 | O-774 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = | IUPAC_name = 7-[(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-3-yl]-7-methyloctanenitrile | image = O-774_structure.png | width = 260 | pregnancy_category = | legal_status = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 10833730 | ChemSpiderID = 9009030 | DrugBank = | C=25|H=35|N=1|O=2 | molecular_weight = 381.550 g/mol | smiles = N#CCCCCCC(c2cc1OC([C@@H]3C/C=C(\\C[C@H]3c1c(O)c2)C)(C)C)(C)C | StdInChI = 1S/C25H35NO2/c1-17-10-11-20-19(14-17)23-21(27)15-18(16-22(23)28-25(20,4)5)24(2,3)12-8-6-7-9-13-26/h10,15-16,19-20,27H,6-9,11-12,14H2,1-5H3/t19-,20-/m1/s1 | StdInChIKey = RVTLXKSJDYALPU-WOJBJXKFSA-N }}O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, with a Ki of 0.6 nM at CB1, and very potent cannabinoid effects in animal studies.[1][2] See also
References1. ^Singer M, et al. Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-Δ8-tetrahydrocannabinol. Journal of Medicinal Chemistry. 1998 Oct 22;41(22):4400-7. {{PMID|9784115}} {{Cannabinoids}}{{cannabinoid-stub}}2. ^The Cannabinoid Receptors. Part I. Cannabinoid Receptor Ligands and Structure-Activity Relationships. pp 6-9. Edited by Patricia H Reggio. Humana Press 2009. {{ISBN|978-1-58829-712-9}} 1 : Cannabinoids |
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