One Big Happy may refer to:

• One Big Happy (comic strip)
• One Big Happy (TV series)

• Desert Stars
• Desert Star Weekly
• Desert Stormer Handicap
• Desert Storm Journal
• Desert Storm (record label)
• Desert Storm (roller coaster)
• Desert Strike Advance
• Desert Strike (computer game)
• Desert Strike (game)
• Desert Strike (video game)
• Deserts (Varese)
• Desert Tactical Arms SRS
• Desert Tactical SRS
• Desert Tech SRS
• Desert Terminal Lakes Program
• Desert thistle
• Desert Tobacco
• Desert Tomato
• Desert Tortoise
• Desert Training Center
• Desert trumpet
• Desertullia
• Desert Valley
• Desert Valley (disambiguation)
• Desert Valley Elementary