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词条 OpenPHACTS
释义

  1. Partnerships

  2. Drug discovery

  3. References

{{short description|Drug discovery organization}}{{Infobox organization
| name = Open PHACTS
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| formation = 2011
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| type = Public–private partnership
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| purpose = Semantic interoperability for drug discovery through Open innovation
| headquarters =
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| membership = 27 member organisations
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| key_people = {{Plainlist|
  • Antony John Williams
  • Carole Goble
  • Barend Mons
  • Gerhard Ecker}}

| website = {{Plainlist|
  • {{URL|www.openphacts.org}}
  • {{URL|https://github.com/openphacts}}}}

| remarks =
}}Open PHACTS (Open Pharmacological Concept Triple Store) is a European initiative public–private partnership between academia, publishers, enterprises, pharmaceutical companies and other organisations working to enable better, cheaper and faster drug discovery.[1][2][3][4] It has been funded by the Innovative Medicines Initiative,[5] selected as part of three projects to "design methods for common standards and sharing of data for more efficient drug development and patient treatment in the future".[6][7]

Partnerships

A total of 27 partners are currently involved including:

  • Academia: Maastricht University, University of Santiago de Compostela, University of Vienna, University of Manchester, University of Bonn, Swiss Institute of Bioinformatics, European Bioinformatics Institute, Vrije Universiteit of Amsterdam, Technical University of Denmark, University of Hamburg
  • Pharmaceutical companies: Pfizer, Merck KGaA, Eli Lilly and Company, Novartis, GlaxoSmithKline, AstraZeneca
  • Other companies: ChemSpider, Biovia, Eagle Genomics, Entagen
  • Publishers: Royal Society of Chemistry, Thomson Reuters

Drug discovery

The Open Pharmacological Space created by the consortium is intended to support open innovation and in-house non-public drug discovery research[8] by removing bottlenecks in drug development.[9][10] Resources from the project are publicly available on GitHub.[11]

To reduce the barriers to drug discovery in industry, academia and for small businesses, the Open PHACTS consortium built the Open PHACTS Discovery Platform. This platform is freely available, integrating pharmacological data from a variety of information resources and providing tools and services to question this integrated data to support pharmacological research.

References

1. ^{{Cite journal | last1 = Williams | first1 = A. J. | authorlink1 = Antony John Williams| last2 = Harland | first2 = L. | last3 = Groth | first3 = P. | last4 = Pettifer | first4 = S. | authorlink4 = Steve Pettifer| last5 = Chichester | first5 = C. | last6 = Willighagen | first6 = E. L. | last7 = Evelo | first7 = C. T. | last8 = Blomberg | first8 = N. | last9 = Ecker | first9 = G. | authorlink9 = Gerhard Ecker| last10 = Goble | first10 = C. | authorlink10 = Carole Goble| last11 = Mons | first11 = B. | authorlink11 = Barend Mons| title = Open PHACTS: Semantic interoperability for drug discovery | doi = 10.1016/j.drudis.2012.05.016 | journal = Drug Discovery Today| volume = 17 | issue = 21–22 | pages = 1188–1198 | year = 2012 | pmid = 22683805 | pmc = }}
2. ^{{Cite journal | last1 = Ecker | first1 = G. F. | last2 = Williams-Jones | first2 = B. | doi = 10.1002/minf.201280004 | title = Open Innovation in Drug Discovery | journal = Molecular Informatics| volume = 31 | issue = 8 | pages = 519 | year = 2012 | pmid = | pmc = }}
3. ^{{Cite journal| first1 = Alasdair J.G. | last1 = Gray| first2 = Paul |last2 = Groth| first3 = Antonis | last3 = Loizou| first4 = Sune | last4 = Askjaer| first5 = Christian | last5 = Brenninkmeijer| first6 = Kees | last6 = Burger| first7 = Christine| last7 = Chichester| first8 = Chris T. | last8 = Evelo| first9 = Carole | last9 = Goble| authorlink9 = Carole Goble| first10 = Lee | last10 = Harland| first11 = Steve| last11 = Pettifer| authorlink11 = Steve Pettifer| first12 = Mark| last12 = Thompson| first13 = Andra| last13 = Waagmeester| first14 = Antony John| last14 = Williams| authorlink14 = Antony John Williams| doi=10.3233/SW-2012-0088| title = Applying linked data approaches to pharmacology: Architectural decisions and implementation| journal = Semantic Web| volume = 5 | issue = 2| pages = 101–113| year = 2014 | pmid = | pmc = | arxiv = 1005.2643}}
4. ^{{Cite journal| pmid = 24267948| year = 2013| author1 = Ciccarese| first1 = P| title = PAV ontology: Provenance, authoring and versioning| journal = Journal of Biomedical Semantics| volume = 4| issue = 1| pages = 37| last2 = Soiland-Reyes| first2 = S| last3 = Belhajjame| first3 = K| last4 = Gray| first4 = A. J.| last5 = Goble| first5 = C| last6 = Clark| first6 = T| doi = 10.1186/2041-1480-4-37}}
5. ^{{cite web |url=http://www.imi.europa.eu/content/open-phacts |title=Open PHACTS at IMI - The Innovative Medicines Initiative |format= |work= |accessdate=}}
6. ^{{Cite journal | last1 = Watson | first1 = R. | doi = 10.1136/bmj.d1577 | title = Europe provides €172m for research into innovative medicines | journal = BMJ | volume = 342 | pages = d1577 | year = 2011 | pmid = 21393337| pmc = }}
7. ^{{Cite book | doi = 10.1007/978-3-642-41338-4_5| chapter = Incorporating Commercial and Private Data into an Open Linked Data Platform for Drug Discovery| title = The Semantic Web – ISWC 2013| volume = 8219| pages = 65| series = Lecture Notes in Computer Science| year = 2013| last1 = Goble | first1 = C. | authorlink1 = Carole Goble| last2 = Gray | first2 = A. J. G. | last3 = Harland | first3 = L. | last4 = Karapetyan | first4 = K. | last5 = Loizou | first5 = A. | last6 = Mikhailov | first6 = I. | last7 = Rankka | first7 = Y. N. | last8 = Senger | first8 = S. | last9 = Tkachenko | first9 = V. | last10 = Williams | first10 = A. J. | authorlink10 = Antony John Williams| last11 = Willighagen | first11 = E. L. | isbn = 978-3-642-41337-7}}
8. ^{{Cite journal | last1 = Müller | first1 = S. | last2 = Weigelt | first2 = J. | title = Open-access public-private partnerships to enable drug discovery--new approaches | journal = IDrugs : the investigational drugs journal | volume = 13 | issue = 3 | pages = 175–180 | year = 2010 | pmid = 20191434}}
9. ^{{Cite journal | last1 = Dalgleish | first1 = R. | last2 = Molero | first2 = E. | last3 = Kidd | first3 = R. | last4 = Jansen | first4 = M. | last5 = Past | first5 = D. | last6 = Robl | first6 = A. | last7 = Mons | first7 = B. | last8 = Diaz | first8 = C. | last9 = Mons | first9 = A. | last10 = Brookes | first10 = A. J. | title = Solving bottlenecks in data sharing in the life sciences | doi = 10.1002/humu.22123 | journal = Human Mutation | volume = 33 | issue = 10 | pages = 1494–1496 | year = 2012 | pmid = 22623360 | pmc = }}
10. ^{{Cite journal | last1 = Mons | first1 = B. | authorlink1 = Barend Mons| last2 = Van Haagen | first2 = H. | last3 = Chichester | first3 = C. | last4 = Hoen | first4 = P. B. 'T. | last5 = Den Dunnen | first5 = J. T. | last6 = Van Ommen | first6 = G. | last7 = Van Mulligen | first7 = E. | last8 = Singh | first8 = B. | last9 = Hooft | first9 = R. | last10 = Roos | doi = 10.1038/ng0411-281 | first10 = M. | last11 = Hammond | first11 = J. | last12 = Kiesel | first12 = B. | last13 = Giardine | first13 = B. | last14 = Velterop | first14 = J. | authorlink14 = Jan Velterop| last15 = Groth | first15 = P. | last16 = Schultes | first16 = E. | title = The value of data | journal = Nature Genetics | volume = 43 | issue = 4 | pages = 281–283 | year = 2011 | pmid = 21445068| pmc = }}
11. ^{{cite web |url=https://github.com/openphacts |title=Open PHACTS on GitHub |format= |work= |accessdate=2012-07-10}}
{{DEFAULTSORT:Open PHACTS}}

3 : Information technology organisations in Europe|Drug discovery|Medical databases
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