Operation Artemis may refer to:

• Operation Artemis, a European Union-led UN authorized military mission to the Democratic Republic of the Congo during the Ituri conflict
• Operation Artemis (Law Enforcement), a Multi-Agency New Mexico Law Enforcement Statewide Operation against Child Pornography Offenders in 2012

• 25383 Lindacker
• 253 AD
• 253 CE
• 253 Medical Regiment
• 253P/PANSTARRS
• 253rd Brigade, Royal Field Artillery
• 253 (year)
• 25/4
• 254299 Shambleau
• 25434 Westonia
• 254422 Henrykent
• .25-45 Sharps
• .25-45 Sharps SRC
• 254749 Kurosawa
• 254846 Csontvary
• 254846 Csontváry
• 254863 Robinwarren
• 254876 Strommer
• 25-48 Edwardes Square
• 254 AD
• 254 CE
• 254 Medical Regiment
• 254mm 45 caliber Pattern 1891
• 254 (number)
• 254P/McNaught