“O-phospho-L-serine—tRNA ligase”的意思、由来-开放百科全书

词条

O-phospho-L-serine—tRNA ligase

释义

References
External links

{{Infobox enzyme
| Name = O-phospho-L-serine---tRNA ligase
| EC_number = 6.1.1.27
| CAS_number =
| IUBMB_EC_number = 6/1/1/27
| GO_code =
| image =
| width =
| caption =
}}

O-phospho-L-serine---tRNA ligase ({{EC number|6.1.1.27}}, O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS) is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase (AMP-forming).^[1]^[2] This enzyme catalyses the following chemical reaction:

ATP + O-phospho-L-serine + tRNACys AMP + diphosphate + O-phospho-L-seryl-tRNACys

In organisms like Archaeoglobus fulgidus, this enzyme ligates O-phosphoserine to tRNACys.

References

1. ^{{cite journal | vauthors = Fukunaga R, Yokoyama S | title = Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea | journal = Nature Structural & Molecular Biology | volume = 14 | issue = 4 | pages = 272–9 | date = April 2007 | pmid = 17351629 | doi = 10.1038/nsmb1219 }}
2. ^{{cite journal | vauthors = Hauenstein SI, Perona JJ | title = Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei | journal = The Journal of Biological Chemistry | volume = 283 | issue = 32 | pages = 22007–17 | date = August 2008 | pmid = 18559341 | pmc = 2494925 | doi = 10.1074/jbc.M801839200 }}

External links

{{MeshName|O-phospho-L-serine---tRNA+ligase}}

{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:O-phospho-L-serine-tRNA ligase}}

1 : EC 6.1.1

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