| 词条 | OSLAM syndrome |
| 释义 |
| name = {{PAGENAME}} | synonyms = Osteosarcoma-limb anomalies-erythroid macrocytosis syndrome | image = Autosomal dominant - en.svg | alt = | caption = OSLAM syndrome is inherited in an autosomal dominant manner | pronounce = | field = | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}OSLAM syndrome is a rare autosomal dominant hereditary disorder. Its name is an initialism of "osteosarcoma, limb anomalies, and erythroid macrocytosis with megaloblastic marrow syndrome". OSLAM syndrome was recognised and described by Mulvilhill {{Abbreviation|et al.|et alia (and others)}} as a syndrome that increases susceptibility to tumours and is characterised by an impaired regulation of bone and marrow development.[1][2] Individuals with OSLAM syndrome have an elevated risk of bone cancer, limb abnormalities, and enlarged red blood cells. Symptoms
Diagnosis{{Empty section|date=August 2017}}Treatment{{Empty section|date=August 2017}}See also
References1. ^Mulvihill J.J., Gralnick H.R., Whang-Peng J., Leventhal B.G. (1977.) Multiple childhood osteosarcomas in an American Indian family with erythoid macrocytosis and skeletal anomalies, Cancer, 40(6):3115–3122. 2. ^Weber G.F. (2007.) Molecular Mechanisms of Cancer, Springer, pg. 558. External links{{Medical resources| ICD10 = C41.9 | ICD9 = | ICDO = | OMIM = 165660 | DiseasesDB = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeSH = C537138 | GeneReviewsNBK = | GeneReviewsName = | Orphanet = 2760 }}{{genetic-disorder-stub}} 4 : Osseous and chondromatous neoplasia|Sarcoma|Hereditary cancers|Syndromes |
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