Ostapenko is a Ukrainian surname that derived from the Ukrainian language name Ostap.

The surname may refer to:

• Aleksey Ostapenko, Russian volleyball player
• Jeļena Ostapenko, Latvian tennis player
• Oleg Ostapenko, Russian former director of Roscosmos, former Deputy Minister of Defence and former commander of the Aerospace Defence Forces
• Oleh Ostapenko Jr., Ukrainian footballer
• Oleh Ostapenko Sr., Ukrainian retired footballer and current manager
• Sergei Ostapenko, Kazakh footballer
• Maksym Ostapenko,
• Serhiy Ostapenko, Ukrainian economist, statesman and political activist.

• Nathaniel Crichlow
• Nathaniel Crosby
• Nathaniel C. Wyeth
• Nathaniel Dance
• Nathaniel Davis Ayer
• Nathaniel Davis (disambiguation)
• Nathaniel Dawayne Hale
• Nathaniel D. Ayer
• Nathaniel Dean
• Nathaniel Deering
• Nathaniel Deutsch
• Nathaniel Dial
• Nathaniel Dickinson
• Nathaniel Dick Wallace
• Nathaniel Dorsky
• Nathaniel Dusk
• Nathaniel Dust
• Nathaniel D. Wallace
• Nathaniel Edwin Harris
• Nathaniel E. Harris
• Nathaniel Eldredge
• Nathaniel Essex
• Nathaniel Exum
• Nathaniel Fick
• Nathaniel Field