| 词条 | Ozenoxacin |
| 释义 |
| drug_name = | INN = | type = | IUPAC_name = 1-Cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | image = Ozenoxacin.svg | alt = | caption = | pronounce = | tradename = Ozanex; Xepi | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = | legal_AU = | legal_AU_comment = | legal_BR = | legal_BR_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = Rx-only | legal_UN = | legal_status = | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = | CAS_number = 245765-41-7 | class = | ATCvet = | ATC_prefix =D06 | ATC_suffix = AX14 | PubChem = 9863827 | ChemSpiderID = 8039521 | DrugBank = | KEGG = D09544 | C=21 | H=21 | N=3 | O=3 | SMILES = O=C\\3c1c(c(c(cc1)c2cc(c(nc2)NC)C)C)N(/C=C/3C(=O)O)C4CC4 | StdInChI = 1S/C21H21N3O3/c1-11-8-13(9-23-20(11)22-3)15-6-7-16-18(12(15)2)24(14-4-5-14)10-17(19(16)25)21(26)27/h6-10,14H,4-5H2,1-3H3,(H,22,23)(H,26,27) | StdInChIKey = XPIJWUTXQAGSLK-UHFFFAOYSA-N }}Ozenoxacin (INN; trade names Ozaenex and Xepi) is a quinolone antibiotic used for the treatment of impetigo.[1] A 1% topical cream is approved for treatment of impetigo in Canada[2] and in the United States.[3] Ozenoxacin is active against some bacteria that have developed resistance to currently used fluoroquinolone antibiotics.[4] References1. ^{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/9863827|title=Ozenoxacin|last=Pubchem|website=pubchem.ncbi.nlm.nih.gov|language=en|access-date=2019-01-10}} {{dermatologic-drug-stub}}2. ^{{cite press release | url = http://www.newswire.ca/news-releases/cipher-pharmaceuticals-receives-health-canada-approval-of-ozanex-ozenoxacin-cream-1-621597383.html | title = Cipher Pharmaceuticals Receives Health Canada Approval of OZANEX (ozenoxacin cream 1%) |publisher = Cipher Pharmaceuticals Inc }} 3. ^{{Cite press release | url = https://www.prnewswire.com/news-releases/medimetriks-pharmaceuticals-inc-receives-fda-approval-for-xepi-ozenoxacin-cream-1-a-novel-topical-antibiotic-for-impetigo-300571024.html | title = Medimetriks Pharmaceuticals, Inc. Receives FDA Approval for Xepi™ (ozenoxacin) Cream, 1%, a Novel Topical Antibiotic for Impetigo | publisher = Medimetriks Pharmaceuticals, Inc.}} 4. ^{{cite journal | journal = Antimicrob Agents Chemother | date = Dec 2013 | volume = 57 | issue = 12| pages = 6389–6392 | doi = 10.1128/AAC.01509-13 | title = In vitro activity of Ozenoxacin against quinolone-susceptible and quinolone-resistant gram-positive bacteria |vauthors=López Y, Tato M, Espinal P, Garcia-Alonso F, Gargallo-Viola D, Cantón R, Vila J | pmid= 24080666 | pmc=3837899}} 4 : Quinolone antibiotics|Cyclopropanes|Carboxylic acids|Pyridines |
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