“Pachymic acid”的意思、由来-开放百科全书

词条

Pachymic acid

释义

Effects
References

{{chembox
| verifiedrevid = 452418850
| ImageFile=Pachymic acid.png
| IUPACName=3-Acetoxy-16-hydroxy-24-methylenelanost-8-en-21-oic acid
| SystematicName=(2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3-acetyloxy-16-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid
| OtherNames=
|Section1={{Chembox Identifiers
| IUPHAR_ligand =
| CASNo_Ref = {{cascite|correct|??}}
| CASNo=29070-92-6
| PubChem=5484385
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 280037
| ChEMBL=468034
| KEGG=C17044
| SMILES = CC(C)C(=C)CC[C@H]([C@H]1[C@@H](C[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)OC(=O)C)C)C)C)O)C(=O)O
| InChI = 1S/C33H52O5/c1-19(2)20(3)10-11-22(29(36)37)28-25(35)18-33(9)24-12-13-26-30(5,6)27(38-21(4)34)15-16-31(26,7)23(24)14-17-32(28,33)8/h19,22,25-28,35H,3,10-18H2,1-2,4-9H3,(H,36,37)/t22-,25-,26+,27+,28+,31-,32-,33+/m1/s1
| InChIKey = VDYCLYGKCGVBHN-DRCQUEPLSA-N
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = JNUUNUQHXIOFDA-XTDASVJISA-N
|Section2={{Chembox Properties
| Formula=C₃₃H₅₂O₅
| MolarMass=528.76 g/mol
| Appearance=
| Density=1.1±0.1 g/cm3
| MeltingPt=
| BoilingPt=612.2±55.0 °C at 760 mmHg
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=184.7±25.0 °C {{CN|date=September 2018}}
| AutoignitionPt =
}}Pachymic acid is a naturally occurring steroid that can be extracted from the parasitic fungus Wolfiporia extensa (synonym Wolfiporia cocos). The dried sclerotia of the fungus is used as a traditional Chinese medicine, and pachymic acid is thought to be the principal bioactive component of it.^[1]

Effects

Pachymic acid is known to inhibit the Epstein-Barr virus and to inhibit the snake venom phospholipase A2.^[2] It also has antitumor and anti-inflammatory properties.^[1]

References

1. ^¹{{cite journal |journal= PLOS ONE |year= 2013 |volume= 8 |issue= 8 |title= De Novo Sequencing and Transcriptome Analysis of Wolfiporia cocos to Reveal Genes Related to Biosynthesis of Triterpenoids |first1= Shaohua |last1= Shu |first2= Bei |last2= Chen |first3= Mengchun |last3= Zhou |first4= Xinmei |last4= Zhao |first5= Haiyang |last5= Xia |first6= Mo |last6= Wang |doi= 10.1371/journal.pone.0071350 |pmc= 3743799 |pmid=23967197 |pages=e71350}}
2. ^{{cite web |url=https://pubchem.ncbi.nlm.nih.gov/compound/Pachymic_acid#section=Biological-Test-Results |title=Pachymic acid Biological Test Results|website=PubChem compound database|date=3 March 2016}}

3 : Lanostanes|carboxylic acids|Acetate esters

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